After the death of Gerry Ryan, Tubridy's friend and colleague, Turbridy was the subject of rumours by various newspapers that he would be succeeding him in the RTÉ 2fm slot, becoming RTÉ's top earner with a salary of €1 million. In June 2010, RTÉ confirmed that Tubridy would in fact fill that slot from August, presenting a programme called Tubridy from 09:00 to 11:00. His salary remained unchanged. In an RTÉ press release, he was quoted as saying: "In my new role on RTÉ 2fm I will be presenting a programme that will be very different, with a different time slot, and a different style of presenting." To allow for presenting The Late Late Show, his show is only 2 two hours long, compared to the 3 hours that Gerry Ryan's show lasted. However JNLR figures released in July 2011 revealed Tubridy had lost over 110,000 listeners since the move.
After finishing The Tubridy Show on 16 July 2010, he began presenting Tubridy on RTÉ 2fm on 20 August 2010, surprising listeners by starting the programme three days earlier that what was originally scheduled for 23 August. His first guest on the programme was Bono. His RTÉ Radio 1 slot was filled by John Murray. Tubridy became synonymous with declining listenership figures, a 40% collapse of which by 2011 coincided with increased listenership figures for its rival The Ray D'Arcy Show.
In July 2010, Tubridy's agent Noel Kelly confirmed that Tubridy was offered by the BBC to present a summer filler for Jonathan Ross's BBC Radio 2 programme. He turned down the offer citing preparations for The Late Late Show and the recent death of Gerry Ryan. It was confirmed that Tubridy would present the slot for 8 weeks from 23 July 2011, covering for Ross' replacement, Graham Norton.
For more than €100,000 HarperCollins signed Tubridy as part of a two-book deal. They wanted an autobiography but he persuaded them otherwise. Tubridy's first book, the 302-page long JFK in Ireland, was launched at the Mansion House, Dublin on 27 October 2010. While researching the book, he discovered that Éamon de Valera had part of John F. Kennedy's speech to Dáil Éireann erased from the record after finding its content offensive. Tubridy is currently working on a second book.
Tubridy co-wrote the title track, "We Are Where We Are", of Paddy Cullivan's extended play, released in October 2010. The writer and broadcaster commented: "Paddy is a pal and we would have conversations a lot over a pint of Guinness". He also sang a song on The Late Late Toy Show in 2010, becoming the first host to do such a thing.
Since then he has been at various times involved with Aoibhinn Ní Shúilleabháin, a presenter of radio and television. Their romance was even referred to as "RyBhinn". Tubridy expressed his dissatisfaction when photos of the couple on a stroll at Powerscourt Waterfall were used by the press and was frustrated by subsequent claims that the photos were a publicity stunt. He later told the Evening Herald (in the week approaching his début as host of The Late Late Show) that Ní Shúilleabháin was "great support" and had transformed his life. In 2010 he told the same newspaper she was "my rock" since the death of friend and colleague Gerry Ryan. In December 2014, Tubridy's agent announced that he and Miss Ní Shúilleabháin had separated, saying 'Aoibhinn and Ryan are no longer together".
Rhys Ifans and Howard Marks appeared on The Late Late Show on 1 October 2010 to discuss Mr. Nice, the British independent film in which Ifans portrayed Marks. During the interview, Ifans was playful with Tubridy, at one point referring to him as a "dainty little bugger" in reference to his cross-legged manner.