Early 2016, Yamada won the Newcomer of the Year category in the 39th Japan Academy Prize for his portrayal of Nagisa Shiota in Assassination Classroom, and Rookie actor of the year in Japan Movie Critics Award for his portrayal of Semi in Grasshopper.
On May 24, 2016, it was announced that Yamada would star as Edward Elric in the Fullmetal Alchemist live-action movie scheduled for release in 2017.
Yamada was cast as the lead to the fall drama of Fuji TV's getsu 9 (prime-time slot), Cain and Abel. It aired in October 2016. It is Yamada's first drama with a romantic love angle, and he is also the first Heisei born from Johnny's to star in a getsu 9. The story is adapted from the Bible's Old Testament, and it is also a remake of the US classic film, East of Eden starring James Dean. Yamada plays a salaryman who falls in love with his brother's girlfriend and is hungry for the affection of his father. For his role in this drama, Yamada was a runner up of Best Leading Actor in the Autumn TV Drama Academy Award 2016. He was also the youngest person to be nominated in the lead actor category that season.
On December 2, 2016, Yamada was cast to lead a movie titled Miracles of the Namiya General Store based on the best-selling novel of the same name by an award-winning writer, Higashino Keigo. The novel was claimed to be one of Higashino's best works. It tells the story of two people living in different eras (1980 and 2012) which will be connected by a letter, a story depicting human bonds and miracles. Yamada will portray a delinquent who stumbles upon a mysterious store that leads to several events that changes his life. The movie will be directed by Ryuichi Hiroki, filming expected to start January 2017 and is slated for Autumn 2017 release.