During 2011, Dupuis played in “the all-female Pavement cover band” Babement. It was formed with Cindy Lou Gooden, of Very Fresh, but they only performed a “couple shows.” Dupuis released two albums with her band Quilty, both released on Cooling Pie Records. The band split up in 2012 while Dupuis pursued Speedy Ortiz. Also during 2012, Dupuis’ side project Dark Warble released an EP entitled Moon is Trouble. Dupuis wrote her first Speedy Ortiz song, “Ka-Prow”, while teaching song writing at Buck’s Rock summer camp in 2011. Speedy Ortiz released its first EP, Cop Kicker, in 2011. Dupuis quit her job and became a full-time musician while preparing for the release of Speedy Ortiz’s second album, Foil Deer. She has also featured in numerous tracks by Ovlov in which she provides backing vocals. In January 2016, Dupuis, under the name Sad13, worked with alternative hip-hop artist Lizzo and recorded the song “Basement Queens”. In November 2016 she released the album Slugger under the same name. In November 2018, she released her first book of poetry, Mouthgard.