Samia was born at Aburi in the Eastern Region of Ghana in 1960. She was forced to leave Ghana with her mother and brothers on the day of the 1966 military coup that overthrew Kwame Nkrumah. The family were resettled in Egypt by the Egyptian government. She returned with her family in 1975 at the invitation of General Acheampong’s National Redemption Council government and attended Achimota School. However, she left the country again when her mother decided to return to Egypt in the early 1980s. Samia proceeded to London, later completing her studies at the School of Oriental and African Studies of the University of London in the United Kingdom, where she obtained the degree of Bachelor Arabic Studies in 1991. She also completed a Master’s degree at the same institution in 1993.

Samia Nkrumah started work as a bank clerk with the London branch of the Bank of India in 1984. She then worked with Al-Ahram as a journalist in various capacities starting from 1989.

She was elected as the first woman chairperson of the Convention People’s Party on 10 September 2011. She won the poll with 1,191 votes, and her nearest contender, the incumbent, polled 353 votes. By this feat, she became the first woman to ever head a major political party in Ghana.