In 2010, Time magazine included Bullock in its annual Time 100 as one of the most influential people in the world. Bullock was selected by People magazine as its 2010 Woman of the Year and ranked number 12 on People's Most Beautiful 2011 list.
Bullock has been a public supporter of the American Red Cross and has donated US$1 million to the organization at least five times. Her first public donation of that amount was to the Red Cross's Liberty Disaster Relief Fund. Three years later, she sent money in response to the 2004 Indian Ocean earthquake and tsunamis. In 2010, she donated US$1 million to relief efforts in Haiti following the Haiti earthquake and again donated the same amount following the 2011 Tōhoku earthquake and tsunami. She donated US$1 million in 2017 to support Red Cross relief efforts for Hurricane Harvey in Texas.
On March 18, 2010, James responded to the rumors of infidelity by issuing a public apology to Bullock. He stated, "The vast majority of the allegations reported are untrue and unfounded ... beyond that, I will not dignify these private matters with any further public comment." James declared, "There is only one person to blame for this whole situation, and that is me." He asked that Bullock and their children one day "find it in their hearts to forgive me" for their "pain and embarrassment". James' publicist subsequently announced on March 30, 2010, that James had checked into a rehabilitation facility to "deal with personal issues" and save his relationship to Bullock. However, on April 28, 2010, it was reported that Bullock had filed for divorce on April 23 in Austin, Texas. Their divorce was finalized on June 28, 2010, with "conflict of personalities" cited as the reason.
Bullock announced on April 28, 2010, that she had proceeded with plans to adopt a son born in January 2010 in New Orleans, Louisiana. Bullock and James had begun an initial adoption process four months earlier. Bullock's son began living with them in January 2010, but they chose to keep the news private until after the Oscars in March 2010. However, given the couple's separation and then divorce, Bullock continued the adoption of her son as a single parent. Bullock announced in December 2015 that she had adopted a second child and appeared on the cover of People magazine with her then three-year-old new daughter.