Salgado was born on February 8, 1944 in Aimorés, in the state of Minas Gerais, Brazil. After a somewhat itinerant childhood, Salgado initially trained as an economist, earning a master’s degree in economics from the University of São Paulo in Brazil. He began work as an economist for the International Coffee Organization, often traveling to Africa on missions for the World Bank, when he first started seriously taking photographs. He chose to abandon a career as an economist and switched to photography in 1973, working initially on news assignments before veering more towards documentary-type work. Salgado initially worked with the photo agency Sygma and the Paris-based Gamma, but in 1979, he joined the international cooperative of photographers Magnum Photos. He left Magnum in 1994 and with his wife Lélia Wanick Salgado formed his own agency, Amazonas Images, in Paris, to represent his work. He is particularly noted for his social documentary photography of workers in less developed nations. They reside in Paris.

Together, Lélia and Sebastião have worked since the 1990s on the restoration of a part of the Atlantic Forest in Brazil. In 1998, they succeeded in turning 17,000 acres into a nature reserve and created the Instituto Terra. The institute is dedicated to a mission of reforestation, conservation and environmental education.

Between 2004 and 2011, Salgado worked on Genesis, aiming at the presentation of the unblemished faces of nature and humanity. It consists of a series of photographs of landscapes and wildlife, as well as of human communities that continue to live in accordance with their ancestral traditions and cultures. This body of work is conceived as a potential path to humanity’s rediscovery of itself in nature.