Ward attended the University of Alabama, where she was Homecoming Queen, a Crimson Tide cheerleader, and joined Chi Omega sorority. She double-majored in fine art and advertising. She graduated in 1977.

Ward eventually moved to California to pursue acting and landed her first film role in the 1983 Burt Reynolds vehicle The Man Who Loved Women. Her first regular role in a television drama series, as a socialite on Dennis Weaver’s short-lived CBS series, Emerald Point N.A.S., followed in the same year. Ward continued to land guest roles in both television and movies throughout the 1980s, most notably opposite Tom Hanks in 1986’s Nothing in Common. In 1991 she was cast as the bohemian alcoholic Teddy Reed on Sisters, for which she received her first Emmy for Outstanding Lead Actress in a Drama Series in 1994. She portrayed Helen Kimball, the wife of Dr. Richard Kimball (Harrison Ford), in The Fugitive, one of the top films of 1993.

On May 23, 1992, Ward married entrepreneur Howard Elliott Sherman. They have two children: Austin and Anabella.

Ward won a CableACE Award for her portrayal of the late television journalist Jessica Savitch in the 1995 TV movie Almost Golden: The Jessica Savitch Story. Almost Golden remains Lifetime’s most watched TV movie to date.

In 1995, Ward was passed over for a Bond girl role, learning that even though then-Bond Pierce Brosnan was 42, the casting director said “What we really want is Sela, but Sela ten years ago”. In response, she developed and produced a documentary, The Changing Face of Beauty, about American obsession with youth and its effect on women. Later on, Ward would voice the part of former model turned villain Page Monroe in an episode (“Mean Seasons”) of The New Batman/Superman Adventures, which focused primarily on the media’s obsession with youth.

After meeting two foster children during a holiday trip home to Mississippi in 1997, Ward decided to meet a broader need for abused and neglected children by initiating and partially funding the creation of a permanent group home and emergency shelter, as well as transition houses. Hope Village for Children opened in Ward’s hometown of Meridian in January 2002, housed on a 30-acre (12 ha) property once used as a Masonic-owned and operated orphanage, and is intended to serve as a pilot for a nationwide network of similar shelters. Hope Village currently has a capacity of 44 residents and serves an average of 200 children per year.

In 2002, Ward published her autobiography, Homesick: A Memoir, through HarperCollins’ ReganBooks imprint. In 2014, Ward was a part of her first group art exhibition at KM Fine Arts.

In 2004, she played the role of a private investigator in the television movie Suburban Madness. The same year, she also appeared in the movie The Day After Tomorrow with Dennis Quaid and Jake Gyllenhaal. In 2005, she began a recurring role in the Fox dramatic series House as Stacy Warner, the hospital’s attorney and formidable ex-partner of the protagonist Dr. Gregory House (played by Hugh Laurie). In 2006, Ward’s character was written off the show. However, she made her last guest appearance in the series finale (which aired on May 21, 2012).

Although she was on a brief hiatus from television, she continued to appear in feature films. She starred opposite Kevin Costner in The Guardian in 2006 and starred in the thriller The Stepfather in 2009. In July 2010, Ward signed on to star in the police drama CSI: NY, at the seventh season’s start. Ward remained on the show until the ninth and final season’s end in February 2013.