On March 9, 2018, Ryder's song "Be the Ones" was chosen to be the official theme song for 2018 Arctic Winter Games.
On April 6, 2018, Ryder released her single "Famous" featuring Simon Ward of The Strumbellas for the US market. Co-written with Simon Wilcox and Simon Ward, "Famous" is a song about society being obsessed with social media and people trying to achieve fame solely for the sake of being famous.
On September 9, 2018, Ryder was invited for a duet with Brett Kissel at the Canadian Country Music Association (CCMA) Awards in Hamilton. The CCMA Awards was hosted by Shania Twain.
On September 23, 2018, Ryder started hosting her own radio program, The Serena Ryder Radio Show on CHFI-FM, which aired across Canada for eight weeks.
On August 11, 2018, Ryder was one of the artists invited to join Billy Talent for the #TorontoStrong benefit concert following the Danforth shooting on July 22, 2018.
On April 4, 2018 Ryder received the Margaret Trudeau Mental Health Advocacy Award for her work with mental health.