When he joined Aligarh Muslim University in 1936, he started participating in inter-college, inter-university mushairas and won frequently. In 1940, he married Salma, who was his distant relative and had been living in a common house with him since childhood, however, the purdah system was vogue in their family and they were not close. After completing his BA, he moved to Delhi as a supply officer, but continued participating in mushairas, earning fame nationwide. Those were the days of shayars who wrote about the downtrodden sections of society, their upliftment, the betterment of society and all. But Shakeel had an altogether different taste – his poetry was romantic and close to the heart. Shakeel used to say:

Shakeel moved to Bombay in 1944, to write songs for films. He met film producer, A.R. Kardar and music composer, Naushad Ali, who asked him to sum up his poetic skills in one line. Shakeel wrote, Hum Dard Ka Afsana Duniya Ko Suna Denge, Har Dil Main Mohabbat Ki Ek Aag Laga Dengey. Naushad immediately retained him for Kardar’s film, Dard (1947). The songs of Dard proved to be very successful, especially Uma Devi (Tun Tun)’s Afsana Likh Rahi Hoon. Only a few are so lucky that they attain success in their first film, but Shakeel deserved success which started with Dard and continued on over the years.

Together, he and Naushad became one of the most sought after composer/lyricist duos in the industry. Among the scores they churned out together, are those of Deedar (1951), Baiju Bawra (1952), Mother India (1957), and Mughal-e-Azam (1960), that stand out. Other films they scored together include Dulari (1949), Shabab (1954), Ganga Jamuna (1961), and Mere Mehboob (1963). Although Shakeel Badayuni worked most extensively with Naushad, he also collaborated with Ravi and Hemant Kumar as well. His lyrics for the song Husnwale Tera Jawab Nahin and Ravi’s music score both won Filmfare Awards for the hit film Gharana. His other notable film with Ravi is Chaudhvin Ka Chand (1960), while Sahib Bibi Aur Ghulam (1962) is his biggest hit with Hemant Kumar. The title song from Chaudhvin Ka Chand, rendered by Mohammed Rafi, won Badayuni the Filmfare Award for Best Lyricist in 1961.

Shakeel Badayuni succumbed to diabetes complications at the age of fifty-three, on 20 April 1970, at Bombay Hospital leaving behind his wife, two sons and two daughters. One daughter, Najma, died soon afterwards, while still a college student. His elder son Javed works in the travel and tourism industry. His other son’s name is Tariq. Shakeel’s friends Ahmed Zakaria and Rangoonwala formed a trust called Yaad-e-Shakeel after his death and this trust became the source of some income to his bereaved family.

A postage stamp, bearing his face, was released by India Post to honour him on 3 May 2013.