The band was on hiatus between 2006 and 2010, with group members focusing on outside projects. On November 23, 2010, System released an official statement declaring that they would play a number of European festivals in 2011, and they played a number of shows in western North America as well.
Odadjian started a side project in May 2006 named AcHoZeN. AcHoZeN is the musical alliance between Odadjian, Wu-Tang Clan founder RZA, Kinetic 9 (aka: Beretta 9 from Killarmy), and up-and-comer, the Reverend William Burke from Chicago. Achozen's mantra is:
Odadjian has described AcHoZeN as "a musical revolution. It is not just a band, it's a way of thinking." RZA and Odadjian anticipate upcoming tours. Achozen also appears on the major motion picture, Babylon A.D., on which AcHoZeN song "Deuces" is heard blaring at the introduction of the film. AcHoZeN's first live show was at the Key Club in L.A on December 1, 2006.
In 2006, Odadjian starred in the critically acclaimed film "Screamers", a documentary by internationally known director Carla Garapedian. The film follows Odadjian and the rest of the rock band System of a Down as they tour Europe and the US, pointing out the horrors of modern genocide that began in Armenia in 1915 up through Darfur today.