2015 marked Ohtani's third professional season (and second full season). Though his offensive production declined somewhat (5 home runs), his performance on the mound was among the best in the league, earning him the starter role in the 2015 All-Star Game and the pitching spot in the end-of-year Pacific League Best Nine awards. Ohtani started 2015 NPB All-Star Game 1 for the PL. He went two innings and fanned two, allowing one run (on a double by Yoshitomo Tsutsugo and a single by Jose Lopez), relieved by Nishi with a 1–0 deficit. The PL would lose 8–6 but he got a no-decision. He finished the season 15–5 with a 2.24 ERA, 196 strikeouts and only 100 hits in 160 2/3 IP. He led the PL in ERA (.14 over Nishi), tied Wakui for the most wins and was second in strikeouts (19 behind Norimoto, though he threw 34 fewer innings). He rarely played the field but did see some action at DH, hitting .202/.252/.376 with 5 HR in 109 AB. He made the Best Nine as the PL's top hurler. He finished third in MVP voting again, placing behind Yanagita and Shogo Akiyama for the 2015 Pacific League MVP. Ohtani placed third in MVP voting (first among pitchers) and was one of three candidates considered for the 2015 Sawamura Award, given annually to the top pitcher in either league.
Ohtani was dominant for the Japanese national team in the 2015 Premier 12. He hit 100 mph while blowing away eventual champion South Korea (10 K, 2 H, 2 BB, 0 R in 6 IP) before Norimoto relieved. Facing South Korea again in the semifinals, he was even sharper (11 K, 0 BB, 1 HB, 1 H in 7 IP). He did not give up a hit until Keun-woo Jeong singled in the 7th and had the most whiffs in a game for the first Premier 12 ever. Norimoto relieved with a 3–0 lead but he and two other relievers combined to allow four in the 9th to blow it as Japan fell in a shocking defeat. He led the event in ERA (Scott Diamond had 12 innings with a 0.00 ERA to Ohtani's 13) and strikeouts (one ahead of Chun-Lin Kuo) while allowing the lowest average by a starting pitcher. He was named the All-Star SP for the event (Sho Nakata was the only other member of Samurai Japan to be picked for the All-Star team).
In the 2015 Premier12, Ohtani earned a bronze medal with the Samurai Japan National Baseball Team. He was the ace of Japan's pitching staff, which featured Kenta Maeda. As the number one starter, Ohtani made two pitching appearances for Japan, both against the Republic of Korea, winning Game 1 of the opening round and getting a no-decision in the semifinals. Ohtani was subsequently named to the 2015 World Baseball Softball Confederation All-World Team and was named the 2015 WBSC Baseball Player of the Year.