In June 2007, Amstell and long-term collaborator Dan Swimer wrote Imagine... A Mildly Amusing Panel Show, a spoof version of Alan Yentob's arts programme Imagine. Yentob and Amstell play themselves in a mock interview between what a number of commentators described as "overtly sexual" clips taken from Amstell's Never Mind the Buzzcocks episodes. It was followed in February 2008 by Never Mind the Buzzcocks: A Moving Tribute, which jokingly implied that Amstell had either died or retired from the show.
Amstell won several awards for his work on Never Mind the Buzzcocks. In March 2007, he won the 2006 Royal Television Society Award for Best Entertainment Performance. In December 2007, he won two British Comedy Awards for Best Comedy Entertainment Personality and Best Comedy Entertainment Series for Never Mind the Buzzcocks. Amstell also received a nomination for the BAFTA for Best Entertainment Performance in 2008; Harry Hill won the award. In addition, Never Mind the Buzzcocks won the Best Entertainment Programme award at the Broadcast Awards 2008. Amstell's era was the reason why Never Mind the Buzzcocks was chosen as the 36th-best TV show of the decade by The Times.
Amstell co-wrote an episode of Channel 4 teenage drama Skins in 2007, titled "Maxxie and Anwar".