At RAI, Ventura appeared with Pippo Baudo on the Sunday afternoon programme “Domenica In” (1991) and then, in 1992, the sports programme “Domenica Sportiva”. She also been on “Pavarotti International”.

In 1996 Simona hosted the newcomers’ section of the Sanremo Music Festival for RAI.

In 1996 Ventura was the Italian voice of Lola Bunny in Space Jam.

In 2001 Simona went back to Rai Due to host the seventh edition of the Sunday afternoon show “Quelli che il calcio” and a prime time show called “Quelli che lo smoking”. In 2002 Pippo Baudo chose her for the “Dopofestival” (a variety show about the Sanremo Music Festival) and she then presented a late night television show with Gene Gnocchi called “La grande notte del lunedì sera”. She has been presenting the Italian version of Celebrity Survivor, L’Isola Dei Famosi since 2003. In 2004 she was host presenter of San Remo Music Festival. In 2005 and 2006 she presented Music farm, a show similar to the Hit Me, Baby, One More Time format, on Rai Due.

She also had the Prime Time Access Rule on Rai Uno with “Le Tre Scimmiette” and in 2007 appeared in prime time with “Colpo di Genio”.

In 2008 Ventura starred in La fidanzata di papà with Massimo Boldi and Elisabetta Canalis.

In 2009 Ventura was trolled by English rock band Muse in her show “Quelli che.. il Calcio”.

In 2010 she had a cameo in Sofia Coppola’s Somewhere.

Simona Ventura led the popular reality show L’isola dei famosi for 8 editions. In the fall of 2009 she abandoned his role as a judge on X Factor. Working on his two most important programs, Simona Ventura in May 2011 will have some problems with the company, the director of RAI 2 Massimo Liofredi tried not to renew the contract of Simona Ventura for this reason, after she signed a contract with Sky.

In 2012, Ventura provided the voice of the pre-match presenter in the EA Sports video game FIFA 13.

In early 2016 Simona Ventura returned in Mediaset as a contestant of the XI season of the popular reality show L’isola dei famosi now hosted by Alessia Marcuzzi with Alvin on Canale 5 and won by Giacobbe Fragomeni.

In the autumn of 2016 Mariano Di Vaio (in couple with the dancer Stefano De Martino) is one of the tutors/mentors of the first season of Selfie – Le cose cambiano, the new talent show produced by Fascino PGT of Maria De Filippi and aired by Canale 5 with Simona Ventura as presenter. Bernardo Corradi (in couple with the dancer Stefano De Martino) in May-June 2017 is one of the tutors/mentors in the second season of Selfie – Le cose cambiano, a talent show produced by Fascino PGT of Maria De Filippi and aired by Canale 5 with Simona Ventura as presenter.