In 2011, Vergara was supposed to star in The Paperboy, an independent drama directed by Lee Daniels. When shooting was delayed for a week and conflicted with her shooting schedule for the third season of Modern Family, she dropped out.
In July 2011, she finished filming the Farrelly brothers' The Three Stooges, her first leading role in a major film. She said, "I play a mean woman that tries to manipulate the Three Stooges into killing her husband so that she gets all the money."
In 2011, Vergara was named the face of CoverGirl, with the first advertisements appearing in January 2012. In April 2011, Vergara appeared in a Diet Pepsi commercial with David Beckham and another in January 2012.
In 2011, it was announced that Vergara was designing a clothing line for Kmart targeting soccer moms and appeared in a number of commercials for Comcast's Xfinity brand and State Farm.
On May 9, 2011, Vergara's younger brother Julio was deported from the United States to Colombia after being arrested in April that year; Julio also had a longtime drug addiction and previous brushes with the law. Vergara told Parade magazine, "To see somebody dying over 10 years, little by little, that's the worst punishment. Now he's like another person."