In the mid-1980s, she became the lead singer for Bob's Your Uncle, a Vancouver alternative rock band. Lee often incorporated performance art techniques into the band's melodic rock. When that band broke up, Lee pursued a solo music career, releasing several solo albums and performing as an actor in theatre, film and television projects. She was the lead singer for the band Slan. Neko Case covered Lee's song "Knock Loud" on her 2001 EP Canadian Amp.
During her last appearance as a MuchMusic VJ in 2001, Lee and her co-host turned their backs to the camera, and mooned the audience on live television.