Lee's Vietnam war film Da 5 Bloods was released on Netflix. The film starred Delroy Lindo, Jonathan Majors, Clarke Peters, Isiah Whitlock Jr., Mélanie Thierry, Paul Walter Hauser and Chadwick Boseman. The film was released worldwide on June 12, 2020. The film's plot follows a group of aging Vietnam War veterans who return to the country in search of the remains of their fallen squad leader, as well as the treasure they buried while serving there. Prior to the COVID-19 pandemic, the film was originally scheduled to premiere out-of-competition at the 2020 Cannes Film Festival, then play in theaters in May or June before streaming on Netflix. The film received widespread critical acclaim with the website Rotten Tomatoes' approval rating being 92% based on 252 reviews, with the critical consensus reading: "Fierce energy and ambition course through Da 5 Bloods, coming together to fuel one of Spike Lee's most urgent and impactful films." On Metacritic, the film has a weighted average score of 82 out of 100, based on 49 critics, indicating "universal acclaim".
In May 2020, he published a 3-minute short film titled NEW YORK NEW YORK on Instagram that was later featured on the city's official website.
In March 2020, a video of Spike was released on Twitter showing the director having an altercation with the security team near the elevators at Madison Square Garden. Speculation arose as to whether Spike was being removed from the building. The New York Knicks released a statement saying, "The idea that Spike Lee is a victim because we have repeatedly asked him to not use our employee entrance and instead use a dedicated VIP entrance — which is used by every other celebrity who enters The Garden — is laughable. He is welcome to come to The Garden anytime via the VIP or general entrance; just not through our employee entrance, which is what he and Jim (James Dolan) agreed to [Monday] night when they shook hands." Spike refuted Dolan's story alleging that he had been using the same entrance for the past 28 years. Lee stated he wouldn't attend the rest of the games for the season.
In June 2020, Lee defended filmmaker Woody Allen despite his sexual abuse allegation during a radio interview stating: "I'd just like to say Woody Allen is a great, great filmmaker and this cancel thing is not just Woody. And I think when we look back on it we are going to see that short of killing somebody, I don't know you that you can just erase somebody like they never existed. Woody's a friend of mine. I know he's going through it right now." Following social media backlash, Lee issued an apology on Twitter.