In 1985, she became director of development at Hill/Obst Productions. In 1987, she became Vice President of Production. In 1991, she became Senior Vice President at Lynda Obst Productions. She went on to work with Danny DeVito and Michael Shamberg at Jersey Films, and now operates Double Feature Films with Michael Shamberg, with whom she co-founded the company. Stacey Sher has worked on many different movies since the 1980s Movies such as Django Unchained, the Hateful Eight, and Pulp Fiction. She got credibility for the 2005 Independent Spirit Award-winning Garden State, and three films with director Steven Soderbergh: Contagion, Erin Brockovich, and Out of Sight.Additional credits include Oliver Stone’s World Trade Center; Matilda; Along Came Polly and many more.

Sher dated director Quentin Tarantino, but their relationship ended during the development of Pulp Fiction, which Sher was a producer on. Sher married musician/producer Kerry Brown in 2001. They have two children.