Dublin surrendered their title to Meath in 2010 in a game which saw Cluxton concede five goals, however, he won a seventh Leinster Championship medal the following year after a 2–12 to 1–12 defeat of Wexford in the final. On 18 September 2011, Cluxton lined out in goal against Kerry in his first All-Ireland final. In the 72nd minute of the game and with the sides level he scored a free kick to secure a 1–12 to 1–11 victory and a first All-Ireland title for Dublin in 16 years. Shortly after the final whistle, Cluxton was presented with the match ball by Tomás Ó Sé, however, in keeping with his intensely private persona, he avoided the post-match celebrations and retreated to the dressing room. Dublin teammate Paul Flynn paid tribute afterwards: "He [Cluxton] is out training an hour before everybody else and he kicks them over with his eyes closed. I didn't even look at the kick. I looked at him and he just kicked it and ran back. He is a phenomenal man, I am delighted for him." Cluxton ended the season by winning a fourth All Star Award as well as being nominated for Footballer of the Year.
Cluxton kept a clean sheet when he played in goal for Ireland in the 2010 International Rules Series in Limerick. Cluxton captained Ireland during the 2011 International Rules Series in Australia. Ireland went on to win the Series.