On April 10, 2015, it was announced that, in coordination with Bristol Motor Speedway, Fox, and Stand Up to Cancer, the 2015 Food City 500 would be renamed the Food City 500 In Support Of Steve Byrnes and Stand Up To Cancer; the race would feature tributes to his legacy as a NASCAR broadcaster, along with his 56th birthday, which fell during the week prior to the race.
Two days after the tribute race, Byrnes died early on April 21, 2015 of complications from his cancer in Fort Mill, South Carolina, just a week after turning 56, and was survived by his wife Karen and son Bryson. In tribute, drivers Josh Wise and Clint Bowyer added photos of Byrnes and his son Bryson to their cars' hoods for the Toyota Owners 400. After Byrnes was invited to become part of the voting panel for the NASCAR Hall of Fame Class of 2016, Bryson delivered his father's completed ballot to the accountants that tally the votes on May 20, 2015, completing Steve's final duties.