He graduated from Hunter College High School in 1997 and received his B.A. from Columbia University’s School of General Studies in 2002. There, Hofstetter wrote for the Columbia Spectator and served as President of the Sigma Phi Epsilon fraternity.

In March 2006, Hofstetter and Razor & Tie announced the April 4 release of Cure for the Cable Guy, a 45-minute CD/DVD that featured a cover with a Larry the Cable Guy Doll hanging by a coax cable. The disc earned Stuff Magazine’s “Album cover of the month”. Later that week, Larry the Cable Guy’s new film debuted and was universally panned. Several movie reviewers discussed Hofstetter’s album, including the Orlando Sentinel’s Roger Moore. Moore’s review was picked up by dozens of papers across the country, including the Chicago Tribune, Denver Post, and Columbus Dispatch. Hofstetter did radio interviews about the album, including one with Philadelphia’s Kidd Chris show, where Hofstetter spoke with Larry the Cable Guy’s alter ego, Dan Whitney. Whitney ended the interview with his catch phrase, “Git-R-Done.”

In December 2007, Hofstetter announced his new album, Dark Side of the Room. Customers can download it directly from his website with “Pay-What-You-Want” à la Radiohead’s 2007 album In Rainbows.

Hofstetter gained a reputation by posting videos of interactions with audience members on YouTube, which garnered so many views that Fox Television offered him a series called Laughs, a half-hour showcase for standup comedians, which debuted in August 2014. Shortly after its premiere, SAG/AFTRA issued a “Do Not Work” notice to its members due to Fox’s choice to make the show a non-union production. This touched off a controversy about whether or not all television shows should be union productions.