Finally, at age 34, Karsay announced his retirement on June 18, 2006, the day after pitching two scoreless innings against the Los Angeles Dodgers and getting the win in a 17-inning marathon for the Athletics. He finished his 11-year Major League career with a 32–39 record, 41 saves, and a 4.01 ERA in 357 career appearances, including 40 starts.