At the time of the 1994 Rwandan genocide, Rice reportedly said, "If we use the word 'genocide' and are seen as doing nothing, what will be the effect on the November election?" She denied the quote but acknowledged the mistakes made at the time and felt that a debt needed repaying. The inability or failure of the Clinton administration to do anything about the genocide would form her later views on possible military interventions. She said of the experience: "I swore to myself that if I ever faced such a crisis again, I would come down on the side of dramatic action, going down in flames if that was required." Later in 2012, during an interview with The New Republic, Rice stated "To suggest that I’m repenting for [Rwanda] or that I’m haunted by that or that I don't sleep at night because of that or that every policy I've implemented subsequently is driven by that is garbage."
Michael E. O'Hanlon and Ivo Daalder, two Brookings colleagues of Rice at the time, said that Rice consistently opposed the 2003 invasion of Iraq in the run-up to the war. In 2012, columnist Peter Beinart reviewed a series of NPR interviews with Rice in late 2002 and early 2003 and concluded that Rice's position on war was equivocal; at some points, she expressed skepticism about U.S. military action, while at other points taking a more hawkish view. Beinart wrote that two of Rice's then-Brookings colleagues at the time were both unsure about her position on the war at the time. For example, in November 2002, Rice said, "many people who think that we haven't finished the war against al Qaeda and our ability to do these simultaneously is in doubt." In a December 2002 NPR interview, Rice said, "It's clear that Iraq poses a major threat. It's clear that its weapons of mass destruction need to be dealt with forcefully, and that's the path we're on. I think the question becomes whether we can keep the diplomatic balls in the air and not drop any, even as we move forward, as we must, on the military side. ... The George W. Bush administration frankly owes the American public a much fuller and more honest assessment of what the costs will be of the actual conflict, as well as the aftermath, the post-conflict reconstruction. And the costs are going to be huge." Rice endorsed the long-standing U.S. policy toward Iraq of regime change, but not necessarily through military means; regarding Rice's allusion to military action, O'Hanlon notes that "For the Clinton administration, they were typically airstrikes or cruise missile strikes of limited duration and effect, not invasions." In a February 2003 NPR interview, Rice said she believed Secretary of State Colin Powell "has proved that Iraq has these weapons and is hiding them, and I don't think many informed people doubted that," but also stated, "there are many who fear that going to war against Iraq may in fact in the short term make us less secure rather than more secure." In her memoir, Rice wrote, "From the start, I viewed that war of choice as a dangerous diversion from the main objective of defeating al-Qaida globally and in Afghanistan." In April 2003, after the war began, Rice said, "To maximize our likelihood of success, the US is going to have to remain committed to and focused on reconstruction and rehabilitation of Iraq for many years to come." Rice said that in the wake of chaos in Iraqi cities in the aftermath of the invasion, the U.S. should act urgently "to fill the security void" and then "transition as quickly as possible these law and order responsibilities to other competent international actors and, of course, ultimately to legitimate Iraqi authorities as quickly as possible."
Three Security Council diplomats took issue with Rice's negotiating style, calling it "rude" and overly blunt, while others attributed those criticisms to sexism. According to David Rothkopf of Foreign Policy magazine, Rice could be challenging to work with due to her "toughness"—in the mold of James Baker or Henry Kissinger—but had the asset of a close relationship with the U.S. president and proved to be an effective policymaker. Some human rights activists took issue with Rice and U.S. foreign policy generally in 2012 for working against UN statements that criticized Rwanda for supporting a rebel group in Congo known for committing atrocities.
In January 2012, after the Russian and Chinese veto of another Security Council resolution calling on Syrian president Bashar al-Assad to step down, Rice strongly condemned both countries, saying, "They put a stake in the heart of efforts to resolve this conflict peacefully," and adding that "we the United States are standing with the people of Syria. Russia and China are obviously with Assad." In her words, "the United States is disgusted that a couple of members of this Council continue to prevent us from fulfilling our sole purpose."
On September 11, 2012, a U.S. diplomatic facility and CIA annex in Benghazi, Libya, was attacked, resulting in the deaths of the United States ambassador to Libya J. Christopher Stevens, U.S. Foreign Service information management officer Sean Smith, and two former Navy SEALS, Glen Doherty and Tyrone S. Woods. On September 16, Rice appeared on five major interview shows to discuss the attacks. Prior to her appearance, Rice was provided with "talking points" from a CIA memo, which stated: