In 2007, Susie won the Miss North Carolina Hawaiian Tropic pageant and went on to compete in the United States Miss Hawaiian Tropic finals in Hawaii. Later that year, she hosted a weekly entertainment segment for North Carolina’s Univision 40 called Muévete Carolina. She also auditioned for America’s Next Top Model and did not even make it to the top house.

In December 2009, Susie won Miss Dominican Republic for Fox Sports en Español’s Premios Fox Sports out of over 50 contestants nationwide. Susie has done promotions for Eurosport, Compare Foods and Wendy’s. In 2010, Susie won Model Of The Year in the Carolina Music Awards. Later that year, she won a national model search featured on Telefutura’s Escandalo TV “Buscando la Modelo del Chapo de Sinaloa.” In 2011 she appeared alongside El Chapo de Sinaloa as the lead model in his music video, “Embrujado.”

In 2009, Susie auditioned for Univision’s Nuestra Belleza Latina. Out of thousands of girls, she was selected as a finalist and to date she is the only girl from North Carolina to have made it to the top 12. She was on the show for two months before she was eliminated. Susie gained international exposure and notoriety through her participation. Susie has been interviewed on various occasions on Univision shows including, Don Francisco Presenta, Despierta America and El Gordo y La Flaca.

Susie De Los Santos has been chosen by producers to compete in the first ever “All★Star” season of Nuestra Belleza Latina, The season of Nuestra Belleza Latina 2016 will premiere on Sunday February 28, 2016. Susie was eliminated from the competition on 3/13/16 as the judge Osmel Souza said that her performance was worse than when she first audition in 2009

In 2010 Susie won model of the year in the Carolina Music Awards.