Hall received her Bachelor of Arts in Broadcast Journalism from Temple University in 1992, after which she moved to the Dallas-Fort Worth area to begin her broadcasting career.

From 1997 to 2007, she worked for WFLD-TV in Chicago, Illinois. She held several positions, including general assignment reporter, consumer reporter, and host of a three-hour program, “Fox News in the Morning”. As a former Chicago resident, Hall frequently reported on issues related to Chicago politics, and covered many “breaking news” stories, including one of the most devastating Amtrak accidents in Illinois.

In 2004, Hall’s sister Renate was murdered, following bouts of domestic violence. Initially, officers informed Hall’s family of their certainty of her attacker’s identity. However, as of this writing, that person has not been brought to justice. During an interview at the Television Critics Association, in January 2014, Hall described the horrific day when she received the call that her sister was found dead face down in her pool. She said there were many signals of domestic abuse that she realized at the time, but she did not do anything to intervene, and also partly blames herself for the death of her sister.

In July 2007, Hall joined the national news network MSNBC and NBC News. She also landed a one-on-one interview with Barack Obama before he announced his run for presidency in 2008.

In 2010, hosted NewsNation with Tamron Hall, which included high-profile interviews and coverage of U.S., global and entertainment news. Airing weekday afternoons, the show covered important American events, including a live television broadcast from Ground Zero in New York City after the death of Osama Bin Laden, the final space shuttle launch in 2011, and Hurricane Isaac in 2012. Hall also encouraged viewers to express their opinions via social media on prominent, controversial news stories.

In July 2013, it was announced that Hall would host Deadline: Crime With Tamron Hall on Investigation Discovery. The weekly newsmagazine series features two crime occurrences per one-hour episode, and debuted on September 1, 2013. In each episode, Hall and her investigative team uncover details on why and how things happened within each case, obtaining information from as many reputable sources as possible. Hall dedicates the series to her older sister, whose death was ruled a homicide in 2004 and remains unsolved.

On February 24, 2014, Hall premiered as co-anchor of Today’s Take (The Today Show’s third hour with Natalie Morales, Al Roker and Willie Geist), becoming the first African American woman to co-anchor Today. On the day she signed the deal, she wore the jacket of American singer and civil rights activist Lena Horne, which she bought from Horne’s estate sale. Horne remains a primary inspiration to Hall.

Hall was featured on a 2014 episode of Running Wild with Bear Grylls where she and Bear Grylls hiked for two days in the Pink Cliffs of southwestern Utah. They rappelled down several cliffs, cooked a squirrel over a fire, and hiked over rugged terrain. She made a guest appearance as herself on General Hospital on September 13, 2019.

In 2014, Today launched the “Shine A Light” campaign, where the show’s anchors each picked a cause to support throughout that year. Hall chose to fight against domestic abuse, with the goal to create a PSA for schools and camps that would spread awareness of emotionally and physically abusive teenage relationships. Hall’s fundraising efforts raised over $40,000 and benefited Day One New York, which helps to fight dating abuse.

On February 1, 2017, with Hall’s contract expiring within the month, NBC News and Hall released a joint statement confirming Hall’s decision to depart from both NBC and MSNBC.

In February 2017, after the network gave her Today co-hosting slot to Megyn Kelly, Hall opted out of her contract and decided to leave NBC rather than take a lesser role.

In July 2017, it was announced that Hall and Harvey Weinstein were producing a daytime talk show that would be hosted and executive produced by Hall. However, Hall’s partnership experienced a setback when the Weinstein sexual misconduct scandal broke.

On August 8, 2018, Hall entered a new agreement with Disney–ABC Domestic Television to executive produce and host a syndicated daytime talk show. The show was picked up by ABC Owned Television Stations in late September 2018. In December 2018, Hearst Television picked up the show for stations in 24 markets, and on January 22, 2019, ABC Entertainment named Bill Geddie as executive producer for the show along with Hall.

On September 9, 2019, Tamron debuted her self-titled award-winning syndicated daytime talk show.

With more than 85% US coverage that includes 47 of the top 50 markets, on March 4, 2019, it was announced that Tamron Hall would debut on September 9, 2019.

Hall is married to music executive Steven Greener and lives in Harlem. In March 2019, Hall revealed that she was expecting her first child. On April 25, 2019, Hall announced that she had given birth to a son named Moses.

In March 2020, Candi Carter joined Tamron Hall as executive producer and showrunner.

In June 2020, Tamron Hall was honored with three Daytime Emmy nominations by the National Academy of Television Arts and Sciences, with Hall’s hosting win marking the first time since the award’s inception in 2015 that a freshman host was the recipient of that honor. Hall also received an NAACP Image Awards nomination for Outstanding Talk Series for Tamron Hall in it’s freshman season and in September 2020, Hall accepted the Gracie Award for Outstanding Talk Show Host and dedicated the honor to Breonna Taylor.