Garber's breakout role was wicked Southern belle Ashton Main in the 1985 ABC miniseries North and South, based on the 1982 novel of the same name by John Jakes. It remains the seventh highest rated miniseries in TV history. Garber reprised the role for the 1986 sequel miniseries, North and South: Book II, as well as for the 1994 final installment, Heaven and Hell: North and South Book III. She described Ashton:
Garber met her first husband, screenwriter Christopher "Chris" Hager, when he was working as a grip on the set of North and South: Book II in 1985. She and Hager are the parents of actress and singer Molly E. Hager (b. 1986). That union ended in divorce in 1989. Her second marriage, to Frank Michael Howson (July 21, 2001 – June 24, 2002), also ended in divorce. In 2013, Garber married director William Roudebush, her former high school drama teacher that she had once been engaged to when she was age 17.