Titi was born in Jakarta. She began singing on public television as a teenager, with ambitions to become a recording artist. At age 17, she represented Indonesia in the Miss World 1983 competition, but was not a finalist. Also a dancer, she performed with Guruh Soekarnoputra’s Swara Mahardhikka troupe. She sang backup vocals for Chrisye and appeared in a few movies early in her career. She released her first solo album in 1984, Imajinasi. Her singing career flourished in the 1990s, with the hit singles “Bintang-Bintang” (“Stars”), “Ekspresi” (“Expression”) and “Salahkah Aku” (“Am I Wrong?”). Currently, she is one of the three Indonesian divas that formed a group together with Krisdayanti and Ruth Sahanaya called 3 Diva.

Titi’s first marriage was to actor Bucek Depp in 1995, with whom she has three children, twin daughters Salma and Salwa Mucthar and a son Daffa Mucthar. The couple divorced in 1997. She went on to marry American teacher Andy Dougharty in 1999, with whom she has one child Stephanie Dougharty. She and Dougharty divorced in 2006. Titi also had a six-year relationship with her musical collaborator, Indra Lesmana. She married Indonesian rock singer Noviar Rachmansyah in 2007, and the couple divorced in August 2011.

In 2010, she appeared as Bunda Ratu in Madame X, an action comedy film about a transgender hairdresser who is also a spy/superhero.

In 2018, she joined the judging panel of the season 3 of The Voice Indonesia.