The Cleveland Browns selected Ward in the second round (38th overall) of the 2010 NFL Draft. He was the fourth safety selected in 2010.
On July 26, 2010, the Cleveland Browns signed Ward to a four-year, $4.02 million contract that includes $3.14 million guaranteed and a signing bonus of $2.07 million.
He made his professional regular season debut in the Cleveland Browns’ season-opener at the Tampa Bay Buccaneers and recorded 11 combined tackles (eight solo) during their 17-14 loss. On October 3, 2010, Ward recorded nine combined tackles during the Browns 23-20 victory against the Cincinnati Bengals in Week 4. During the fourth quarter, Ward was penalized for delivering a hit to the head of Bengals’ wide receiver Jordan Shipley. Shipley was carted off the field and was diagnosed with a concussion. On October 6, 2010, the league issued Ward a $15,000 fine for the hit that drew national attention and was widely criticized. On November 21, 2010, Ward made five solo tackles, two pass deflections, and intercepted two passes during a 24-20 loss at the Jacksonville Jaguars in Week 11. Ward made his first career interception off a pass attempt by quarterback David Garrard, that was initially intended for wide receiver Mike Thomas, and returned it for a 16-yard gain during the third quarter. In Week 14, he collected a season-high 12 combined tackles (ten solo) during a 13-6 loss at the Buffalo Bills. He started all 16 games as a rookie in 2010 and recorded 123 combined tackles (95 solo), ten pass deflections, two interceptions, and one forced fumble.