Though del Rio retired from adult films in 1984, in part due to the AIDS scare prevalent at the time, she returned to make six final films in 1986/87, following a stint as a bodybuilder, including the faux biopic Deep Inside Vanessa del Rio and The Devil in Miss Jones 3 for the notorious punk-inspired Dark Brothers. She then worked as a feature dancer and magazine model until tearing the meniscus in her knee onstage in 1996. After that she used her coding skills to create her own website, produce original content, continued to appear in magazines, and made special appearances at award shows and conventions. During and after her porn career she appeared on many TV shows as herself, including a 1996 episode of NYPD Blue. In 2008, she made a cameo opposite Bernie Mac in the film Soul Men.