Guzzo was born on 11 June 1969 in Montreal, the only son of Italian immigrants. Guzzo attended Selwyn House School, a private boys’ school in Westmount, Quebec where his classmates included Greg Fergus and Michael Penner. A 19 September 2018 profile in the Montreal Gazette talks about his early life:

Guzzo and his wife Maria have five children (Angelo, Vittorio Emanuele, Vito, Delano and Rossella). Maria heads the Guzzo Family Foundation, founded in 2007, which raises money for the Jewish General Hospital, the Shriners Hospital and Youth Mental Health. Guzzo holds both Canadian and Italian citizenships.

The first episode of season 13 including the two new “Dragons” Vincenzo Guzzo and Lane Merrifield aired on September 20, 2018. Dragons’ Den is a popular Canadian TV show on the CBC Television network, with an average of 519,000 viewers per episode in the 2017-2018 season.

In May 2019, Guzzo submitted a bid to purchase the Montreal Alouettes of the Canadian Football League. He later pulled out of the running to buy the team, citing “personal conflicts with people around the deal.” Guzzo later tweeted in a series of threads that he did not believe that CFL commissioner Randy Ambrosie knew what he was doing during negotiations and acted “in a non transparent way and wasted my time.”

Guzzo is the president and CEO of Cinémas Guzzo — the largest movie operator in Quebec, with 141 screens and 10 locations, and the third-largest in Canada. His new cinema Méga-Plex St-Jean 12 is currently being built, scheduled to open in 2020.