Rhames was born on May 12, 1959 in Harlem, New York City, the son of Reather, a homemaker, and Ernest Rhames, an auto mechanic. His parents were raised as sharecroppers in South Carolina. He was named after NBC journalist Irving R. Levine.

He entered New York’s High School of Performing Arts, where he discovered his love of acting. After high school, he studied drama at SUNY Purchase, where fellow acting student Stanley Tucci gave him his nickname “Ving”. Rhames later transferred to the Juilliard School’s Drama Division (Group 12: 1979–1983) where he graduated with a Bachelor of Fine Arts degree in 1983.

Rhames first appeared on Broadway in the play The Boys of Winter in 1984. He started out in film in Wes Craven’s The People Under the Stairs (1991) as Leroy, watched over Kevin Kline as Secret Service agent Duane Stevensen in Dave (1993), and played Marsellus Wallace in Pulp Fiction (1994). He also played the buddy of George Clooney in Out of Sight (1998).

Rhames played Dr. Peter Benton’s brother-in-law on the TV medical drama ER, a recurring role he filled for three seasons. He played ace computer hacker Luther Stickell opposite Tom Cruise in Brian De Palma’s Mission: Impossible (1996). In 1997, Rhames portrayed the character of Nathan ‘Diamond Dog’ Jones in the popular film Con Air, and Muki in the Ice Cube film Dangerous Ground.

Rhames won a Golden Globe in 1998 for Best Actor – Miniseries or Television Film in HBO’s Don King: Only in America. At the ceremony he gave his award to fellow nominee Jack Lemmon, saying, “I feel that being an artist is about giving, and I’d like to give this to you.” Lemmon was clearly touched by the gesture as was the celebrity audience who gave Lemmon a standing ovation. Lemmon, who tried unsuccessfully to give the award back to Rhames, said it was “one of the nicest, sweetest moments I’ve ever known in my life.” The Hollywood Foreign Press Association announced later that they would have a duplicate award prepared for Rhames. That moment was #98 on E!’s 101 Awesome Moments in Entertainment. The New York Times lauded Rhames for the act, writing that in doing so he “demonstrated his capacity for abundant generosity.”

In March 2005, Rhames played the lead role on a new Kojak series, on the USA Network cable channel (and on ITV4 in the UK). The bald head, lollipops, and “Who loves ya, baby?” catchphrase remained intact, but little else remained from the Telly Savalas-starring original.

In the 2008 film Saving God, he played an ex-con who is released from prison a changed man, looking to take over his father’s former church congregation in a deteriorating neighborhood. Rhames stars in Phantom Punch, a biopic of boxer Sonny Liston, released directly to DVD, as well as The Tournament, portraying a fighter out to win a no-rules tournament.

He filmed the movie The Red Canvas with Ernie Reyes Jr., UFC lightweight contender Gray Maynard, and Randy Couture. In 2010, he filed a lawsuit against the film’s producer, claiming that he had only been paid $175,000 of a $200,000 contract.

Since 2014, Rhames has provided the narration for numerous Arby’s commercials, with the catchphrase “Arby’s: We have the meats!”

In 2015, he filmed a series of commercials for The ADT Corporation.

Rhames narrated the team introductions for the New England Patriots and Atlanta Falcons in Super Bowl LI in February 2017.