Born Von B’Vsean Miller Jr. on March 26, 1989 in Dallas, he attended DeSoto High School in DeSoto, Texas, playing for the DeSoto Eagles high school football team and ran track. In his junior year, he recorded 37 tackles, 14 tackles for loss, 7 sacks and 12 quarterback hurries. As a senior, he was named the District 8-5A Defensive MVP after making 76 tackles, 14 tackles for loss and 6 sacks. He played with future Aggie teammate Cyrus Gray.

Considered a four-star recruit by Rivals.com, Miller was listed as the No. 15 weakside defensive end in the nation in 2007. He chose Texas A&M over offers from Florida, Ole Miss, Oklahoma and Texas Tech.

Miller attended Texas A&M University, where he played for the Texas A&M Aggies football team from 2007 to 2010. As a freshman at defensive end in 2007, he was named Freshman All-Big 12 by The Sporting News after posting 22 tackles, including 10 solo stops. He recorded two sacks, four tackles for loss, and a forced fumble. He played in a 4-2-5 defense. He weighed 220 pounds during his freshman year.

In Spring 2008, newly hired head coach Mike Sherman was discouraged by Miller’s habits of skipping class and failing to produce during practice. Sherman decided to suspend Miller for that spring. Disappointed, Miller considered transferring, but upon his father’s insistence, stayed. Miller then adopted a more serious attitude.

As a sophomore in 2008, Miller played at weakside linebacker under Joe Kines’s 4–3 defense. He saw action in all 12 games, making 44 tackles, including 25 solo stops, and leading the team with 3.5 sacks. He made 7.5 tackles for loss, forced two fumbles, and recovered two more. His role was more confined to pass coverage, as opposed to rushing the quarterback, thus he wasn’t able to showcase his pass-rushing abilities. In the final seven Big 12 games, he compiled just eight tackles.

As a junior in 2009, Miller adopted the role of the jack position, a defensive end/linebacker hybrid, which allowed him to utilize his pass rushing abilities. He enjoyed a breakout season for the Aggies, leading the nation in sacks with 17 and ranking fourth in the nation with 21 tackles for loss. For his efforts, Von Miller was named first team All Big-12 at defensive end and was named a first-team All-American by Sporting News and Sports Illustrated. He became the first Aggie to be named a first team All-American since Jason Webster in 1999. Then-Aggies defensive coordinator Joe Kines compared Miller to the late Derrick Thomas. Miller then studied and watched film of Thomas to familiarize himself with his game.

As a senior in 2010, Miller switched to playing as a 3–4 outside linebacker under Tim DeRuyter’s defense. Early in the season, Miller suffered a high ankle sprain that held him back for the first six games. He posted 10.5 sacks and 17.5 tackles for loss. Again he made first-team All-Big 12 honors and won the Butkus Award as the nation’s top linebacker. He was also named a consensus first-team All-American. He received first team All-American honors from Walter Camp, Scout.com, Pro Football Weekly, ESPN.com and the Associated Press. Miller graduated with a degree in poultry science and raises chickens in his spare time.

Miller was projected to be a second round pick in the 2010 NFL Draft had he passed on his senior season. He entered the 2011 NFL Draft regarded as one of the best 3–4 outside linebackers available by NFL draft experts and scouts and was projected to be a top five draft pick. At the 2011 Senior Bowl, Miller was the Defensive MVP. Among linebackers at the 2011 NFL Combine, Miller ranked 2nd in the 40-yard dash, 3rd in the vertical jump, 1st in the broad jump, 3rd in the 20-yard shuttle, T-1st in the 3-cone drill, and 1st in the 60-yard shuttle. His 11.15-second 60-yard shuttle broke the combine linebacker record. At the Texas A&M Pro Day in March 2011, Miller ran a 4.49 40-yard dash.

In March 2011, Miller was selected to represent top flight rookies in the NFL Labor Union talks. He was persuaded by former NFL running back LaDainian Tomlinson to join the lawsuit. During the Texas A&M Pro Day, however, one scout compared him to Hall of Famer Derrick Thomas, while Bengals defensive coordinator Mike Zimmer compared him to Cardinals linebacker Joey Porter. NFL Network Analyst Mike Mayock, who rated Miller as the second-best player in the draft, stated that Miller reminds him of a smaller version of DeMarcus Ware. Miller’s then-personal trainer, Dan Brandenburg, who also worked with first round picks Clay Matthews III and Sean Weatherspoon, stated Miller is the best athlete of all three.

Miller was drafted by the Denver Broncos second overall in the 2011 NFL Draft. He was the highest selected linebacker since LaVar Arrington went No. 2 to the Washington Redskins in 2000. He also became the Aggies’ highest draft pick since Quentin Coryatt, who was selected second overall in 1992. The selection of Miller surprised certain experts. Denver was switching from a 3–4 defense to a 4–3, a defense which seemed counter-intuitive to Miller’s strengths. Former Broncos quarterback John Elway, who is also the executive vice president of the franchise, said Miller is “a type of guy that comes around every 10 years”. On July 28, 2011, Miller signed his rookie contract. He wears No. 58 in honor of Pro Football Hall of Fame linebacker Derrick Thomas.

On September 12, 2011, in his first career play from scrimmage, Miller forced a fumble against the Oakland Raiders. On September 18, 2011, he had his first sack on Andy Dalton when the Broncos played the Cincinnati Bengals.

Miller got off to a quick start in his second season, registering 10 sacks in nine games. In this period, he recorded 30 quarterback hurries, more than he had during his entire 2011 campaign. Thanks to this tremendous start, he was considered an MVP candidate. On November 16, he was fined $21,000 for a hit on Carolina Panthers quarterback Cam Newton in Week 10. He received his second career AFC Defensive Player of the Week honor after recording three sacks and two forced fumbles against the San Diego Chargers the following week. For his efforts during the month of November, he was awarded AFC Defensive Player of the Month. On December 26, 2012, he was announced the starting Outside Linebacker in the AFC division for the 2013 Pro Bowl. Miller finished the season third in sacks with eighteen and a half, breaking a Denver Broncos record of seventeen previously held by Elvis Dumervil. He also capped off the 2012 season finishing second in voting for Defensive Player of the Year and being named first-team All-Pro. In the Divisional Round of the playoffs, Miller had nine total tackles and two quarterback hits in the 38–35 2OT loss to the Baltimore Ravens.

In 2012, Miller teamed up with Ubisoft, makers of the video game The Hip Hop Dance Experience, to create his very own sack celebration dance called “The DeSoto Shuffle” that was inspired by the video game. Each time he performed the dance during a game, Ubisoft made a charitable donation to Von’s Vision, a foundation devoted to providing eye care and glasses to underprivileged youth.

In 2012, Miller created Von’s Vision to provide Denver-area youth with eye examinations and eyewear. Von’s Vision hosts Von’s Vision Days throughout the year to provide children with free eye exams and glasses. The organization hosts two events for Denver-area children: Von’s Vision Day and Von Miller’s Back to School Vision Day. Von’s Vision Day is a two-day program. The foundation partners with national and regional eyewear retailers to provide a citywide vision day for low-income Denver children. On the first day of the program, children receive free screenings, and if needed, free eye exams and an invitation to pick up their corrective eyewear at a later date. After the prescription glasses have been cut, Miller hosts a party where children are fitted for their glasses. Children have the opportunity to interact with Von Miller and feel comfortable in their new glasses.

In July 2013, ESPN reported that Miller had been suspended four games for violating league policy, pending appeal. He tweeted that he did “nothing wrong”. In August 2013, he lost the appeal and was suspended for six games. The six-game suspension arose after the NFL learned that he attempted to cheat a drug test. He became eligible to play on October 20, 2013, when the Broncos played the Indianapolis Colts. On November 24, in a loss to the New England Patriots, he recovered a Stevan Ridley fumble and took it 60 yards for a touchdown. It was the second touchdown of his career. He did fairly well upon his return, but his season was ended prematurely when he tore his ACL on December 22, 2013 during a win on the road at the Houston Texans. Without Miller, the Broncos reached Super Bowl XLVIII, but lost 43–8 to the Seattle Seahawks.

Miller was born in Dallas, Texas, to parents Von and Gloria Miller. His parents, who were both athletes in high school and college, own a power supply business. He has a younger brother Vinsynzie “Vins”. Having majored in poultry science at Texas A&M, Miller operates his own farm, raising chickens. In August 2013, Miller was arrested on a failure to appear warrant for driving-related charges in October 2012. In September 2013, Miller was cited for speeding and driving with a suspended license in Arapahoe County, Colorado. Miller was referenced in South Park during the season 20 episode “Oh, Jeez” when Gerald Broflovski is sent to Denmark under the alias “Ambassador Von Miller”; this has been one of the show’s numerous references to the Broncos, as many characters living in the series’s titular town are fans of the team.

On September 17, 2015, Miller became the third-fastest player in NFL history to reach 50 sacks career (58 games). The only ones to get there faster than him were Reggie White (40 games) and Derrick Thomas (54). Overall, in the 2015 season, Miller finished with 11 sacks, 35 total tackles, 32 quarterback hits, one pass defensed, and four forced fumbles.

On March 1, 2016, the Broncos placed the exclusive franchise tag on Miller. On July 15, Miller signed a 6-year deal worth $114.5 million featuring $70 million guaranteed with the Broncos. He became the highest paid defensive player in NFL history, with the highest amount of guaranteed salary.

On March 8, 2016, Miller was announced as one of the celebrities who would compete on season 22 of Dancing with the Stars. He was partnered with professional dancer Witney Carson. On May 2, 2016, during a double elimination, Miller and Carson were eliminated and finished the competition in 8th place. In April 2018, while on a guided fishing tour off the coast of Florida, Miller is alleged to have illegally landed a hammerhead shark. In April 2020, Miller was diagnosed with COVID-19, recovering from it by the following month.

On December 19, 2017, Miller was named to his sixth Pro Bowl. Miller was named the 2018 Pro Bowl defensive MVP. In the 2017 season, he recorded his fourth consecutive season with at least ten sacks. He was ranked ninth by his fellow players on the NFL Top 100 Players of 2018.

During the 2018 season, Miller recorded his 100th career sack (including postseason sacks), becoming the 5th-fastest player in NFL history to do so. He was also selected to the 2019 Pro Bowl as a starting outside linebacker, which was his seventh career and fifth consecutive Pro Bowl.

During practice on September 8, 2020, Miller suffered what was called a “freak injury near the ankle”, and it was feared that season-ending surgery was required. An MRI the next day revealed that the injury was a dislocated peroneal tendon, and Miller was subsequently placed on injured reserve.