Waka Flocka came to fame with his breakthrough single “O Let’s Do It” in 2009, which peaked at number 62 on the US Billboard Hot 100. Waka Flocka is a member of 1017 Brick Squad with Gucci Mane, OJ Da Juiceman, Frenchie, and Wooh Da Kid. On January 19, 2010, Malphurs was shot and robbed at a car wash in Atlanta. The bullet went through his right arm. His debut album, Flockaveli, was released on October 1, 2010. The album debuted at number six on the US Billboard 200. The album was inspired by Tupac Shakur, whose final stage name and pseudonym before his death was Makaveli. He was named the eighth hottest MC of 2010 by MTV.

In 2011, Waka Flocka posed for a nude but not revealing picture for PETA, to boycott killing animals and wearing fur. The picture says “ink not mink”. Waka Flocka released several mixtapes in 2011, including Salute Me or Shoot Me 3, Benjamin Flocka and his last Twin Towers 2 (No Fly Zone) with fellow rapper Slim Dunkin. On August 9, 2011, his collaborative album with Gucci Mane, titled Ferrari Boyz, was released. The first single was “She Be Puttin On”, featuring the now deceased Slim Dunkin, who was shot at an Atlanta recording studio while shooting a music video.

“Round of Applause”, featuring Canadian rapper Drake, was released on October 14, 2011 as the first single from his second studio album, Triple F Life: Friends, Fans & Family. It was produced by frequent collaborator, Lex Luger. The album itself was released on June 8, 2012.

On January 3, 2011, Waka Flocka turned himself in to authorities in Atlanta following a previous raid on his home. He was booked on possession of marijuana, hydrocodone, possession of a firearm by a convicted felon, and violation of probation for driving on a suspended license. On January 5, 2011, he was released after posting bail.

On January 22, 2013, Waka Flocka announced that he has completed his third studio album, titled Flockaveli 2. He revealed the album will feature guest appearances from Timbaland and Wyclef Jean. Also the album will be mainly produced by longtime producers of 808 Mafia, Lex Luger, Southside, TM88 and more. On February 5, 2013, Waka Flocka released his mixtape DuFlocka Rant 2 with guest appearances from Gucci Mane, Lil Wayne, French Montana, Ace Hood and Young Scooter, among others. On May 9, 2013, he released a sequel, titled DuFlocka Rant: Halftime Show which features fellow Southern rapper T.I.. Flockaveli 2 was then rescheduled for release in early 2014, and on October 4, 2013, Flocka released another mixtape From Roaches to Rollies. On October 31, 2013, Waka Flocka confirmed that Ne-Yo and Drake would be featured on Flockaveli 2.

On March 15, 2013, Gucci Mane announced that frequent collaborator and close friend Waka Flocka Flame was “dropped” from 1017 Brick Squad Records. The two rappers proceeded to throw insults back and forth on Twitter. Though it was reported that Gucci’s Twitter account was hacked, Waka stated, “Dont let da media fool u. This shit real Shawty.” On March 27, 2013, during an MTV Jams interview with Sway Calloway, Waka explained that he would never do music nor business with Gucci ever again. Neither of the rappers have explained where the controversy originated from. Waka has stated, “I guess we both be at the finish line we just going our own routes. That’s all I can say. What’s the reason? Sometimes it’s none of your fuckin’ business what’s the reason. Just understand two men went they own ways but it’s no problem.” In October 2013, Waka Flocka released a diss track towards Gucci Mane titled “Ice Cream”.

On November 19, 2013, it was revealed Gucci Mane had filed a lawsuit against Waka Flocka Flame, Waka’s mother Debra Antney, OJ Da Juiceman, rapper Khia Stone and producer Zaytoven. The lawsuit accuses the parties of fraud, racketeering, and breach of contract. According to Gucci Mane, Waka’s mother Antney took control of his 1017 Brick Squad Records, LLC., without permission, and used it to create three separate offshoot labels. Gucci also accused the parties in the lawsuit of withholding royalties and inflating the cost of label expenditures. In his lawsuit, Gucci Mane also says that Antney took more than the typical 20 percent management fee. Gucci Mane also alleges that Antney’s actions led to his having money and tax problems.

In December 2013, Waka Flocka’s younger brother and fellow rapper KayO Redd committed suicide at his home in Henry County, Georgia. On January 24, 2014, during an interview, Waka Flocka spoke on his brother’s passing:

On March 21, 2014, Waka Flocka released a mixtape entitled Re-Up. In a July 2014 interview with XXL Waka Flocka confirmed producers on the album will include 808 Mafia, Lex Luger, Mike Will Made-It and Black Metaphor. He also announced a new EDM album titled Turn Up God to be released in late 2014. On July 14, 2014 Waka Flocka would release a mixtape entitled I Can’t Rap Vol. 1. On November 10, 2014 Waka Flocka released the front cover art for Flockaveli 2.

In 2014, Waka Flocka appeared in the third season of the VH1 show Love & Hip Hop: Atlanta. The show loosely follows events in the life of Waka Flocka and his wife, Tammy Rivera. On September 23, 2014, the couple announced that they would be starring in their own spin-off, Meet the Flockas.

On October 10, 2014, Waka Flocka was arrested at Hartsfield-Jackson Atlanta International Airport when a security scan turned up a loaded handgun in his luggage. He was released two hours later.

Waka Flocka Flame would post a tweet on September 20, 2014 to his verified Twitter account that included an old picture of himself and Gucci Mane with the caption “… #NoBeef “, confirming that the two had buried the hatchet.

On March 2, 2015, Waka Flocka released a collaboration mixtape with DJ Whoo Kid entitled The Turn Up Godz Tour, with guest appearances from Future, Howard Stern, Machine Gun Kelly, Offset, Cash Out, Bobby V, Gucci Mane, Tony Yayo, and Watch The Duck. On April 1, 2015 Waka Flocka released the mixtape Salute Me Or Shoot Me 5, with guest appearances from Future, Yo Gotti and Juvenile. Waka Flock released another mixtape, titled Flockaveli 1.5, on November 25, 2015.

In April 2015 Waka Flocka did a collaboration campaign with Rolling Stone magazine in which he pretended to run for president. Although he was 7 years too young to be considered president, the campaign, directed by Sam Lipman Stern of Live from the Streets, went viral and was picked up by dozens of media outlets such as CNN, La Times, Washington Post and many more.

On October 3, 2020, Waka Flocka received an honorary doctorate in philanthropy and humanitarianism from the Bible Institute of America Theological Seminary, credited to his charity and mental health advocacy.