Rooney made his return to the first team as a substitute against Wigan on 20 November. Four days later, he returned to the starting line-up and scored a penalty in a 1–0 away win over Rangers in the Champions League. He missed a penalty in a 1–0 home win over Arsenal on 13 December. His first goal of the season from open play came on 1 January 2011 in a 2–1 away win over West Bromwich Albion. On 1 February, Rooney scored twice and provided an assist for Nemanja Vidić in a 3–1 home win over Aston Villa. On 12 February, Rooney scored an overhead bicycle kick in the 78th minute of the Manchester derby, which proved to be the winning goal in their 2–1 win over Manchester City. After the match, Rooney said it was the best goal of his career, before Sir Alex Ferguson described the strike as the best goal he had ever witnessed at Old Trafford. Two weeks later, he scored the third goal in a 4–0 away win over Wigan, before opening the scoring in a 2–1 away loss to Chelsea on 1 March. Rooney scored the second goal in a 2–0 home win over Arsenal in an FA Cup tie on 12 March.
On 14 May 2011, Rooney scored a penalty for United to equalise in a 1–1 draw against Blackburn at Ewood Park in the penultimate game of the Premier League season – enough to secure a record 19th top division title for United, and giving Rooney his fourth Premier League title winner's medal.
Rooney started the season with a goal in the first league game at The Hawthorns against West Bromwich Albion. Rooney played a one-two with Ashley Young before a sharp turn and finish from outside the box which found the bottom corner of the goal. He also scored in the second game of the season, at home to Tottenham Hotspur, when he headed in a Ryan Giggs cross. In late August, Rooney scored his 150th goal for United, the first of a hat-trick, helping to beat Arsenal 8–2. Rooney won man of the match, scoring two free kicks, a penalty, and also contributing an assist for Nani. On 10 September, Rooney scored another hat-trick in a 5–0 away win over Bolton Wanderers on 10 September, becoming only the fourth player in Premier League history to score a hat-trick in consecutive games. These goals brought him level with Bobby Charlton on seven United hat-tricks, joint fourth on the all-time list behind Denis Law, Jack Rowley and Dennis Viollet. After the fallout from his red card against Montenegro on international duty, Rooney was left out of the starting line-up against Liverpool on 15 October 2011. He returned to action on 18 October 2011, where he scored two goals in the Champions League group stage match against Oțelul Galați and surpassed his former teammate Paul Scholes as the highest-scoring Englishman in Champions League history.
Despite the letter, UEFA punished Rooney with a three-game ban, meaning that he could not play in any of the group stage matches. After UEFA's announcement, Džudović stated that he believed the sentence for Rooney was too severe and that he would defend him if needed. He later asked the UEFA to pardon Rooney. The FA then decided they would appeal to UEFA against the ban. On 8 December 2011, after the FA had appealed the ban, UEFA reduced the sentence to two matches. This meant that Rooney missed the matches against France and Sweden. He was able to play in the final match of the group stage against Ukraine on 19 June 2012, scoring the only goal of the game, allowing England to progress to the quarter-finals. England were eventually knocked out in the quarter-finals against Italy, who, after a scoreless 120 minutes, won 4–2 on penalties, although Rooney was able to net his spot-kick. After another international tournament in which the English media criticised Rooney's performances, Fabio Capello claimed Rooney "only plays well in Manchester."
In July 2011, jerseys with Rooney's name and number (Rooney, 10) were the best-selling sports product under the auspices of the Premier League – taking over top spot from Liverpool striker Fernando Torres (Torres, 9) and becoming the first United player to top the list since Cristiano Ronaldo's number 7 jersey in 2008. During the 2009–10 season, Manchester United sold between 1.2 million and 1.5 million shirts and it is estimated that of that, Rooney's name was printed on several hundred thousand. The account is taken from official jerseys sales across the globe, not just in England.