Some of Ford's totals were depressed by Yankees' manager Casey Stengel, who viewed Ford as his top pitching asset and often reserved his ace left-hander for more formidable opponents such as the Cleveland Indians and Chicago White Sox. When Ralph Houk became the manager in 1961, he promised Ford that he would pitch every fourth day, regardless of the opponent; after exceeding 30 starts only once in his nine seasons under Stengel, Ford had 39 in 1961. Indeed 1961 was his first 20-win season, a career-best 25–4 record, and the Cy Young Award ensued, but Ford's season was overshadowed by the home run battle between Roger Maris and Mickey Mantle. As a left-hander with an excellent pick-off move, Ford was also deft at keeping runners at their base: He set a record in 1961 by pitching 243 consecutive innings without allowing a stolen base.
Ford admitted to doctoring the ball in the 1961 All Star Game at Candlestick Park to strike out Willie Mays. Ford and Mantle had accumulated $1,200 ($10,143 today) in golf pro shop purchases as guests of Horace Stoneham at the Giants owner's country club. Stoneham promised to pay their tab if Ford could strike out Mays. "What was that all about?" Mays asked. "I'm sorry, Willie, but I had to throw you a spitter," Ford replied.
During his MLB career, Ford had 10 World Series victories, more than any other pitcher. Ford also leads all starters in World Series losses (8) and starts (22), as well as innings, hits, walks, and strikeouts. In 1961, he broke Babe Ruth's World Series record of 29 ⁄3 consecutive scoreless innings. The record eventually reached 33 ⁄3, although MLB rule-makers retroactively reduced the record to 33 innings since Ford did not complete a full inning before allowing the streak-ending run. It is still a World Series record, although Mariano Rivera broke it as a postseason record in 2000. Ford won the 1961 World Series MVP Award. He appeared on eight AL All-Star teams between 1954 and 1964.