Burroughs was born in 1914, the younger of two sons born to Mortimer Perry Burroughs (June 16, 1885 – January 5, 1965) and Laura Hammon Lee (August 5, 1888 – October 20, 1970). His was a prominent family of English ancestry in St. Louis, Missouri. His grandfather, William Seward Burroughs I, founded the Burroughs Adding Machine company, which evolved into the Burroughs Corporation. Burroughs’ mother was Laura Hammond Lee Burroughs whose brother, Ivy Lee, was an advertising pioneer later employed as a publicist for the Rockefellers. His father ran an antique and gift shop, Cobblestone Gardens in St. Louis; and later in Palm Beach, Florida when they relocated.

As a boy, Burroughs lived on Pershing Avenue (now Pershing Place) in St. Louis’ Central West End. He attended John Burroughs School in St. Louis where his first published essay, “Personal Magnetism” – which revolved around telepathic mind-control – was printed in the John Burroughs Review in 1929. He then attended the Los Alamos Ranch School in New Mexico, which was stressful for him. The school was a boarding school for the wealthy, “where the spindly sons of the rich could be transformed into manly specimens”. Burroughs kept journals documenting an erotic attachment to another boy. According to his own account, he destroyed these later, ashamed of their content. He kept his sexual orientation concealed from his family well into adulthood, due to the context in which he grew up and from which he fled – that is, a “family where displays of affection were considered embarrassing”. He became a well-known homosexual writer after the publication of Naked Lunch in 1959. A common story says that he was expelled from Los Alamos after taking chloral hydrate in Santa Fe with a fellow student. Yet, according to his own account, he left voluntarily: “During the Easter vacation of my second year I persuaded my family to let me stay in St. Louis.”

Burroughs finished high school at Taylor School in Clayton, Missouri, and in 1932 left home to pursue an arts degree at Harvard University, where he was affiliated with Adams House. During the summers, he worked as a cub reporter for the St. Louis Post-Dispatch, covering the police docket. He disliked the work, and refused to cover some events, like the death of a drowned child. He lost his virginity in an East St. Louis, Illinois brothel that summer with a female prostitute whom he regularly patronized. While at Harvard, Burroughs made trips to New York City and was introduced to the gay subculture there. He visited lesbian dives, piano bars, and the Harlem and Greenwich Village homosexual underground with Richard Stern, a wealthy friend from Kansas City. They would drive from Boston to New York in a reckless fashion. Once, Stern scared Burroughs so badly that he asked to be let out of the vehicle.

Burroughs graduated from Harvard in 1936. According to Ted Morgan’s Literary Outlaw,

After Burroughs graduated from Harvard, his formal education ended, except for brief flirtations with graduate study of anthropology at Columbia and medicine in Vienna, Austria. He traveled to Europe and became involved in Austrian and Hungarian Weimar-era LGBT culture; he picked up young men in steam baths in Vienna and moved in a circle of exiles, homosexuals, and runaways. There, he met Ilse Klapper, née Herzfeld (1900–1982), a Jewish woman fleeing the country’s Nazi government. The two were never romantically involved, but Burroughs married her, in Croatia, against the wishes of his parents, to allow her to gain a visa to the United States. She made her way to New York City, and eventually divorced Burroughs, although they remained friends for many years. After returning to the United States, he held a string of uninteresting jobs. In 1939, his mental health became a concern for his parents, especially after he deliberately severed the last joint of his left little finger at the knuckle to impress a man with whom he was infatuated. This event made its way into his early fiction as the short story “The Finger.”

Burroughs enlisted in the U.S. Army early in 1942, shortly after the bombing of Pearl Harbor brought the United States into World War II. But when he was classified as a 1-A infantry, not an officer, he became dejected. His mother recognized her son’s depression and got Burroughs a civilian disability discharge – a release from duty based on the premise that he should have not been allowed to enlist due to previous mental instability. After being evaluated by a family friend, who was also a neurologist at a psychiatric treatment center, Burroughs waited five months in limbo at Jefferson Barracks outside St. Louis before being discharged. During that time he met a Chicago soldier also awaiting release, and once Burroughs was free, he moved to Chicago and held a variety of jobs, including one as an exterminator. When two of his friends from St. Louis – University of Chicago student Lucien Carr and his admirer, David Kammerer – left for New York City, Burroughs followed.

In 1944, Burroughs began living with Joan Vollmer Adams in an apartment they shared with Jack Kerouac and Edie Parker, Kerouac’s first wife. Vollmer Adams was married to a G.I. with whom she had a young daughter, Julie Adams. Burroughs and Kerouac got into trouble with the law for failing to report a murder involving Lucien Carr, who had killed David Kammerer in a confrontation over Kammerer’s incessant and unwanted advances. This incident inspired Burroughs and Kerouac to collaborate on a novel titled And the Hippos were Boiled in their Tanks, completed in 1945. The two fledgling authors were unable to get it published, but the manuscript was eventually published in November 2008 by Grove Press and Penguin Books.

Oliver Harris has questioned Burroughs’ claim that Vollmer’s death catalysed his writing, highlighting the importance for Queer of Burroughs’ traumatic relationship with the boyfriend fictionalized in the story as Eugene Allerton, rather than the shooting of Vollmer. In any case, he had begun to write in 1945. Burroughs and Kerouac collaborated on And the Hippos Were Boiled in Their Tanks, a mystery novel loosely based on the Carr–Kammerer situation and that at the time remained unpublished. Years later, in the documentary What Happened to Kerouac?, Burroughs described it as “not a very distinguished work”. An excerpt of this work, in which Burroughs and Kerouac wrote alternating chapters, was finally published in Word Virus, a compendium of William Burroughs’ writing that was published by his biographer after his death in 1997.

During this time, Burroughs began using morphine and became addicted. He eventually sold heroin in Greenwich Village to support his habit. Vollmer also became an addict, but her drug of choice was Benzedrine, an amphetamine sold over the counter at that time. Because of her addiction and social circle, her husband immediately divorced her after returning from the war. With urging from Allen Ginsberg, and also perhaps Kerouac, Burroughs became intellectually and emotionally linked with Vollmer and by summer 1945, had moved in with Vollmer and her daughter. In spring 1946, Burroughs was arrested for forging a narcotics prescription. Vollmer asked her psychiatrist, a Dr. Wollberg, to sign a surety bond for Burroughs’ release. As part of his release, Burroughs returned to St. Louis under his parents’ care, after which he left for Mexico to get a divorce from Ilse Klapper. Meanwhile, Vollmer’s addiction led to a temporary psychosis that resulted in her admission to Bellevue Hospital, which endangered the custody of her child. Upon hearing this, Burroughs immediately returned to New York City to gain her release, asking her to marry him. Their marriage was never formalized, but she lived as his common-law wife. They returned to St. Louis to visit Burroughs’ parents and then moved with her daughter to Texas. Vollmer soon became pregnant with Burroughs’ child. Their son, William S. Burroughs Jr., was born in 1947. The family moved briefly to New Orleans in 1948.

The only newspaper columnist Burroughs admired was Westbrook Pegler, a right-wing opinion shaper for the William Randolph Hearst newspaper chain. Burroughs believed in frontier individualism, which he championed as “our glorious frontier heritage on minding your own business.” Burroughs came to equate liberalism with bureaucratic tyranny, viewing government authority as a collective of meddlesome forces legislating the curtailment of personal freedom. According to his biographer Ted Morgan, his philosophy for living one’s life was to adhere to a laissez-faire path, one without encumbrances – in essence a credo shared with the capitalist business world. His abhorrence of the government did not prevent Burroughs from using its programs to his own advantage. In 1949 he enrolled in Mexico City College under the GI Bill, which paid for part of his tuition and books and provided him with a seventy-five-dollar-per-month stipend. He maintained, “I always say, keep your snout in the public trough.”

Burroughs fled to Mexico to escape possible detention in Louisiana’s Angola state prison. Vollmer and their children followed him. Burroughs planned to stay in Mexico for at least five years, the length of his charge’s statute of limitations. Burroughs also attended classes at the Mexico City College in 1950, studying Spanish, as well as “Mexican picture writing” (codices) and the Mayan language with R. H. Barlow.

Before killing Vollmer, Burroughs had largely completed his first novel, Junkie, which was written at the urging of Allen Ginsberg, who was instrumental in getting the work published, even as a cheap mass-market paperback. Ace Books published the novel in 1953 as part of an Ace Double under the pen name William Lee, retitling it Junkie: Confessions of an Unredeemed Drug Addict (it was later republished as Junkie, then in 1977 as Junky, and finally in 2003 as Junky: the definitive text of ‘Junk’, edited by Oliver Harris’).

During 1953, Burroughs was at a loose end. Due to legal problems, he was unable to live in the cities toward which he was most inclined. He spent time with his parents in Palm Beach, Florida, and New York City with Allen Ginsberg. When Ginsberg refused his romantic advances, Burroughs went to Rome to meet Alan Ansen on a vacation financed from his parents’ continuing support. He found Rome and Ansen’s company dreary and, inspired by Paul Bowles’ fiction, he decided to head for the Tangier International Zone, where he rented a room and began to write a large body of text that he personally referred to as Interzone.

To Burroughs, all signs directed a return to Tangier, a city where drugs were freely available and where financial support from his family would continue. He realized that in the Moroccan culture he had found an environment that synchronized with his temperament and afforded no hindrances to pursuing his interests and indulging in his chosen activities. He left for Tangier in November 1954 and spent the next four years there working on the fiction that would later become Naked Lunch, as well as attempting to write commercial articles about Tangier. He sent these writings to Ginsberg, his literary agent for Junkie, but none was published until 1989 when Interzone, a collection of short stories, was published. Under the strong influence of a marijuana confection known as majoun and a German-made opioid called Eukodol, Burroughs settled in to write. Eventually, Ginsberg and Kerouac, who had traveled to Tangier in 1957, helped Burroughs type, edit, and arrange these episodes into Naked Lunch.

Excerpts from Naked Lunch were first published in the United States in 1958. The novel was initially rejected by City Lights Books, the publisher of Ginsberg’s Howl; and Olympia Press publisher Maurice Girodias, who had published English-language novels in France that were controversial for their subjective views of sex and antisocial characters. But Allen Ginsberg managed to get excerpts published in Black Mountain Review and Chicago Review in 1958. Irving Rosenthal, student editor of Chicago Review, a quarterly journal partially subsidized by the university, promised to publish more excerpts from Naked Lunch, but he was fired from his position in 1958 after Chicago Daily News columnist Jack Mabley called the first excerpt obscene. Rosenthal went on to publish more in his newly created literary journal Big Table No. 1; however, the United States Postmaster General ruled that copies could not be mailed to subscribers on the basis of obscenity laws. John Ciardi did get a copy and wrote a positive review of the work, prompting a telegram from Allen Ginsberg praising the review. This controversy made Naked Lunch interesting to Girodias again, and he published the novel in 1959.

Whereas Junkie and Queer were conventional in style, Naked Lunch was his first venture into a nonlinear style. After the publication of Naked Lunch, a book whose creation was to a certain extent the result of a series of contingencies, Burroughs was exposed to Brion Gysin’s cut-up technique at the Beat Hotel in Paris in October 1959. He began slicing up phrases and words to create new sentences. At the Beat Hotel Burroughs discovered “a port of entry” into Gysin’s canvases: “I don’t think I had ever seen painting until I saw the painting of Brion Gysin.” The two would cultivate a long-term friendship that revolved around a mutual interest in artworks and cut-up techniques. Scenes were slid together with little care for narrative. Perhaps thinking of his crazed physician, Dr. Benway, he described Naked Lunch as a book that could be cut into at any point. Although not considered science fiction, the book does seem to forecast AIDS, liposuction, and the crack pandemic.

Burroughs moved into a rundown hotel in the Latin Quarter of Paris in 1959 when Naked Lunch was still looking for a publisher. Tangier, with its political unrest, and criminals with whom he had become involved, became dangerous to Burroughs. He went to Paris to meet Ginsberg and talk with Olympia Press. He left behind a criminal charge which eventually caught up with him in Paris. Paul Lund, a British former career criminal and cigarette smuggler whom Burroughs met in Tangier, was arrested on suspicion of importing narcotics into France. Lund gave up Burroughs, and evidence implicated Burroughs in the importation of narcotics into France. When the Moroccan authorities forwarded their investigation to French officials, Burroughs faced criminal charges in Paris for conspiracy to import opiates. It was during this impending case that Maurice Girodias published Naked Lunch; its appearance helped to get Burroughs a suspended sentence, since a literary career, according to Ted Morgan, is a respected profession in France.

The actual process by which Naked Lunch was published was partly a function of its “cut-up” presentation to the printer. Girodias had given Burroughs only ten days to prepare the manuscript for print galleys, and Burroughs sent over the manuscript in pieces, preparing the parts in no particular order. When it was published in this authentically random manner, Burroughs liked it better than the initial plan. International rights to the work were sold soon after, and Burroughs used the $3,000 advance from Grove Press to buy drugs (equivalent to approximately $26,000 in today’s funds). Naked Lunch was featured in a 1959 Life magazine cover story, partly as an article that highlighted the growing Beat literary movement. During this time Burroughs found an outlet for material otherwise rendered unpublishable in Jeff Nuttall’s My Own Mag. Also, poetry by Burroughs’ appeared in the avant garde little magazine Nomad at the beginning of the 1960s.

Burroughs left Paris for London in 1960 to visit Dr. Dent, a well-known English medical doctor who spearheaded a reputedly painless heroin withdrawal treatment using the drug apomorphine. Dent’s apomorphine cure was also used to treat alcoholism, although it was held by several people who undertook it to be no more than straightforward aversion therapy. Burroughs however was convinced. Following his first cure, he wrote a detailed appreciation of apomorphine and other cures, which he submitted to The British Journal of Addiction (Vol. 53, 1956) under the title “Letter From A Master Addict To Dangerous Drugs”; this letter is appended to many editions of Naked Lunch.

After leaving Mexico, Burroughs drifted through South America for several months, seeking out a drug called yagé, which promised to give the user telepathic abilities. A book composed of letters between Burroughs and Ginsberg, The Yage Letters, was published in 1963 by City Lights Books. In 2006, a re-edited version, The Yage Letters Redux, showed that the letters were largely fictionalised from Burroughs’ notes.

After the novel was published, it slowly became notorious across Europe and the United States, garnering interest from not just members of the counterculture of the 1960s, but also literary critics such as Mary McCarthy. Once published in the United States, Naked Lunch was prosecuted as obscene by the Commonwealth of Massachusetts, followed by other states. In 1966, the Massachusetts Supreme Judicial Court declared the work “not obscene” on the basis of criteria developed largely to defend the book. The case against Burroughs’ novel still stands as the last obscenity trial against a work of literature – that is, a work consisting of words only, and not including illustrations or photographs – prosecuted in the United States.

Burroughs played Opium Jones in the 1966 Conrad Rooks cult film Chappaqua, which also featured cameo roles by Allen Ginsberg, Moondog, and others. In 1968, an abbreviated – 77 minutes as opposed to the original’s 104 minute – version of Benjamin Christensen’s 1922 film Häxan was released, subtitled Witchcraft Through The Ages. This version, produced by Antony Balch, featured an eclectic jazz score by Daniel Humair and expressionist narration by Burroughs. He also appeared alongside Brion Gysin in a number of short films in the 1960s directed by Balch. Jack Sargeant’s book Naked Lens: Beat Cinema details Burroughs’ film work at length, covering his collaborations with Balch and Burroughs’ theories of film.

Though he ultimately relapsed, Burroughs ended up working out of London for six years, traveling back to the United States on several occasions, including one time escorting his son to the Lexington Narcotics Farm and Prison after the younger Burroughs had been convicted of prescription fraud in Florida. In the “Afterword” to the compilation of his son’s two previously published novels Speed and Kentucky Ham, Burroughs writes that he thought he had a “small habit” and left London quickly without any narcotics because he suspected the U.S. customs would search him very thoroughly on arrival. He claims he went through the most excruciating two months of opiate withdrawal while seeing his son through his trial and sentencing, traveling with Billy to Lexington, Kentucky from Miami to ensure that his son entered the hospital that he had once spent time in as a volunteer admission. Earlier, Burroughs revisited St. Louis, Missouri, taking a large advance from Playboy to write an article about his trip back to St. Louis, one that was eventually published in The Paris Review, after Burroughs refused to alter the style for Playboy’s publishers. In 1968 Burroughs joined Jean Genet, John Sack, and Terry Southern in covering the 1968 Democratic National Convention for Esquire magazine. Southern and Burroughs, who had first become acquainted in London, would remain lifelong friends and collaborators. In 1972, Burroughs and Southern unsuccessfully attempted to adapt Naked Lunch for the screen in conjunction with American game-show producer Chuck Barris.

In 1974, concerned about his friend’s well-being, Allen Ginsberg gained for Burroughs a contract to teach creative writing at the City College of New York. Burroughs successfully withdrew from heroin use and moved to New York. He eventually found an apartment, affectionately dubbed “The Bunker”, on the Lower East Side of Manhattan at 222 Bowery. The dwelling was a partially converted YMCA gym, complete with lockers and communal showers. The building fell within New York City rent control policies that made it extremely cheap; it was only about four hundred dollars a month until 1981 when the rent control rules changed, doubling the rent overnight. Burroughs added “teacher” to the list of jobs he did not like, as he lasted only a semester as a professor; he found the students uninteresting and without much creative talent. Although he needed income desperately, he turned down a teaching position at the University at Buffalo for $15,000 a semester. “The teaching gig was a lesson in never again. You were giving out all this energy and nothing was coming back.” His savior was the newly arrived twenty-one-year-old bookseller and Beat Generation devotee James Grauerholz, who worked for Burroughs part-time as a secretary as well as in a bookstore. Grauerholz suggested the idea of reading tours. Grauerholz had managed several rock bands in Kansas and took the lead in booking for Burroughs reading tours that would help support him throughout the next two decades. It raised his public profile, eventually aiding in his obtaining new publishing contracts. Through Grauerholz, Burroughs became a monthly columnist for the noted popular culture magazine Crawdaddy, for which he interviewed Led Zeppelin’s Jimmy Page in 1975. Burroughs decided to relocate back to the United States permanently in 1976. He then began to associate with New York cultural players such as Andy Warhol, John Giorno, Lou Reed, Patti Smith, and Susan Sontag, frequently entertaining them at the Bunker; he also visited venues like CBGB to watch the likes of Patti Smith perform. Throughout early 1977, Burroughs collaborated with Southern and Dennis Hopper on a screen adaptation of Junky. It was reported in The New York Times that Burroughs himself would appear in the film. Financed by a reclusive acquaintance of Burroughs, the project lost traction after financial problems and creative disagreements between Hopper and Burroughs.

In 1976, Burroughs was having dinner with his son, William S. “Billy” Burroughs Jr., and Allen Ginsberg in Boulder, Colorado, at Ginsberg’s Buddhist poetry school (Jack Kerouac School of Disembodied Poetics) at Chogyam Trungpa’s Naropa University when Billy began to vomit blood. Burroughs Sr. had not seen his son for over a year and was alarmed at his appearance when Billy arrived at Ginsberg’s apartment. Although Billy had successfully published two short novels in the 1970s and was deemed by literary critics like Ann Charters as a bona fide “second generation beat writer”, his brief marriage to a teenage waitress had disintegrated. Billy was a constant drinker, and there were long periods when he was out of contact with any of his family or friends. The diagnosis was liver cirrhosis so complete that the only treatment was a rarely performed liver transplant operation. Fortunately, the University of Colorado Medical Center was one of two places in the nation that performed transplants under the pioneering work of Dr. Thomas Starzl. Billy underwent the procedure and beat the thirty-percent survival odds. His father spent time in 1976 and 1977 in Colorado, helping Billy through additional surgeries and complications. Ted Morgan’s biography asserts that their relationship was not spontaneous and lacked real warmth or intimacy. Allen Ginsberg was supportive to both Burroughs and his son throughout the long period of recovery.

Burroughs, by 1979, was once again addicted to heroin. The cheap heroin that was easily purchased outside his door on the Lower East Side “made its way” into his veins, coupled with “gifts” from the overzealous if well-intentioned admirers who frequently visited the Bunker. Although Burroughs would have episodes of being free from heroin, from this point until his death he was regularly addicted to the drug. In an introduction to Last Words: The Final Journals of William S. Burroughs, James Grauerholz (who managed Burroughs’ reading tours in the 1980s and 1990s) mentions that part of his job was to deal with the “underworld” in each city to secure the author’s drugs.

In 1981, Billy Burroughs died in Florida. He had cut off contact with his father several years before, even publishing an article in Esquire magazine claiming his father had poisoned his life and revealing that he had been molested as a fourteen-year-old by one of his father’s friends while visiting Tangier. The liver transplant had not cured his urge to drink, and Billy suffered from serious health complications years after the operation. After he had stopped taking his transplant rejection drugs, he was found near the side of a Florida highway by a stranger. He died shortly afterward. Burroughs was in New York when he heard from Allen Ginsberg of Billy’s death.

Burroughs moved to Lawrence, Kansas in 1981, taking up residence at 1927 Learnard Avenue where he would spend the rest of his life. He once told a Wichita Eagle reporter that he was content to live in Kansas, saying, “The thing I like about Kansas is that it’s not nearly as violent, and it’s a helluva lot cheaper. And I can get out in the country and fish and shoot and whatnot.” In 1984, he signed a seven-book deal with Viking Press after he signed with literary agent Andrew Wylie. This deal included the publication rights to the unpublished 1952 novel Queer. With this money he purchased a small bungalow for $29,000. He was finally inducted into the American Academy and Institute of Arts and Letters in 1983 after several attempts by Allen Ginsberg to get him accepted. He attended the induction ceremony in May 1983. Lawrence Ferlinghetti remarked the induction of Burroughs into the Academy proved Herbert Marcuse’s point that capitalistic society had a great ability to incorporate its one-time outsiders.

Burroughs narrated part of the 1980 documentary Shamans of the Blind Country by anthropologist and filmmaker Michael Oppitz. He gave a reading on Saturday Night Live on November 7, 1981, in an episode hosted by Lauren Hutton.

During 1982, Burroughs developed a painting technique whereby he created abstract compositions by placing spray paint cans in front of blank surfaces, and then shooting at the paint cans with a shotgun. These splattered and shot panels and canvasses were first exhibited in the Tony Shafrazi Gallery in New York City in 1987. By this time he had developed a comprehensive visual art practice, using ink, spray paint, collage and unusual things such as mushrooms and plungers to apply the paint. He created file-folder paintings featuring these mediums as well as “automatic calligraphy” inspired by Brion Gysin. He originally used the folders to mix pigments before observing that they could be viewed as art in themselves. He also used many of these painted folders to store manuscripts and correspondence in his personal archive Until his last years, he prolifically created visual art. Burroughs’ work has since been featured in more than fifty international galleries and museums including Royal Academy of the Arts, Centre Pompidou, Guggenheim Museum, ZKM Karlsruhe, Sammlung Falckenberg, New Museum, Irish Museum of Modern Art, Los Angeles County Museum, and Whitney Museum of American Art.

Burroughs continues to be named as an influence by contemporary writers of fiction. Both the New Wave and, especially, the cyberpunk schools of science fiction are indebted to him. Admirers from the late 1970s – early 1980s milieu of this subgenre include William Gibson and John Shirley, to name only two. First published in 1982, the British slipstream fiction magazine Interzone (which later evolved into a more traditional science fiction magazine) paid tribute to him with its choice of name. He is also cited as a major influence by musicians Roger Waters, David Bowie, Patti Smith, Genesis P-Orridge, Ian Curtis, Lou Reed, Laurie Anderson, Tom Waits and Kurt Cobain.

In 1983 director Howard Brookner released Burroughs: the Movie. The film is perhaps the definitive account of Burroughs’ life, and Brookner and Burroughs maintained a very close collaboration during the shooting process. The film features interviews with many of Burroughs’ friends and collaborators including Allen Ginsberg, Brion Gysin, Francis Bacon, Herbert Huncke, Patti Smith and Terry Southern.

He is featured in a spoken word piece entitled “Sharkey’s Night” on Laurie Anderson’s 1984 album Mister Heartbreak, but the longer version of this track, with additional dialogue from Burroughs, was released only on a promotional 4-track 12″ Ep (Warner Bros PRO-A-2123). In addition, Burroughs provided vocal samples for the soundtrack of Anderson’s 1986 concert film, Home of the Brave, and made a cameo appearance in it.

By this point, Burroughs was a counterculture icon. In his final years, he cultivated an entourage of young friends who replaced his aging contemporaries. He inspired 1970s proto-punk rock band Doctors of Madness. In the 1980s he collaborated with performers ranging from Bill Laswell’s Material and Laurie Anderson to Throbbing Gristle, The Disposable Heroes of Hiphoprisy and Ministry, and in Gus Van Sant’s 1989 film Drugstore Cowboy, playing a character based on a short story he published in Exterminator!, “The “Priest” They Called Him”, featuring a guitar track supplied by Kurt Cobain of Nirvana. Burroughs and R.E.M. collaborated on the song “Star Me Kitten” on the Songs in the Key of X: Music From and Inspired By The X-Files album. A collaboration with musicians Nick Cave and Tom Waits resulted in a collection of short prose, Smack My Crack, later released as a spoken word album in 1987. In 1990, he released the spoken word album Dead City Radio, with musical back-up from producers Hal Willner and Nelson Lyon, and alternative rock band Sonic Youth. He collaborated with Tom Waits and director Robert Wilson on The Black Rider, a play which opened at the Thalia Theatre in Hamburg in 1990 to critical acclaim, and that was later performed all over Europe and the U.S. In 1991, with Burroughs’ approval, director David Cronenberg adapted Naked Lunch into a feature film, which opened to critical acclaim.

In 1990, Burroughs was honored with a star on the St. Louis Walk of Fame.

In 1990, Island Records released Dead City Radio, a collection of readings set to a broad range of musical compositions. It was produced by Hal Willner and Nelson Lyon, with musical accompaniment from John Cale, Donald Fagen, Lenny Pickett, Chris Stein, Sonic Youth, and others. The remastered edition of Sonic Youth’s album Goo includes a longer version of “Dr. Benway’s House”, which had appeared, in shorter form, on Dead City Radio.

In June 1991, Burroughs underwent triple bypass surgery.

In 1992 he recorded “Quick Fix” with Ministry, which appeared on their single for “Just One Fix”. The single featured cover art by Burroughs and a remix of the song dubbed the “W.S.B. mix”. Burroughs also made an appearance in the video for “Just One Fix”. The same year he also recorded the EP The “Priest” They Called Him; Burroughs reads the short story of the same name, while Kurt Cobain creates layers of guitar feedback and distortion. Nirvana bassist Krist Novoselic is featured on the cover as the titular “Priest”. The track on the 13th Ministry album “Thanx but No Thanx” makes use of William S. Burroughs’ poem “A Thanksgiving Prayer”, as read by Sgt. Major.

In 1992 Burroughs worked with The Disposable Heroes of Hiphoprisy on Spare Ass Annie and Other Tales, with the duo providing musical background and accompaniment to Burroughs’ spoken readings from several of his books. A 12″ EP was released with five different remixes of the Spare Ass Annie track “Words of Advice for Young People”, all done by Bill Laswell.

He became a member of a chaos magic organization, the Illuminates of Thanateros, in 1993.

Since 1997, several posthumous collections of Burroughs’ work have been published. A few months after his death, a collection of writings spanning his entire career, Word Virus, was published (according to the book’s introduction, Burroughs himself approved its contents prior to his death). Aside from numerous previously released pieces, Word Virus also included what was promoted as one of the few surviving fragments of And the Hippos Were Boiled in Their Tanks, a novel by Burroughs and Kerouac (later published in 2008). A collection of journal entries written during the final months of Burroughs’ life was published as the book Last Words in 2000. Publication of a memoir by Burroughs entitled Evil River by Viking Press has been delayed several times; after initially being announced for a 2005 release, online booksellers indicated a 2007 release, complete with an ISBN number ( ISBN 0670813516), but it remains unpublished. In December 2007, Ohio State University Press released Everything Lost: The Latin American Journals of William S. Burroughs. Edited by Oliver Harris, the book contains transcriptions of journal entries made by Burroughs during the time of composing Queer and The Yage Letters, with cover art and review information. In addition, restored editions of numerous texts have been published in recent years, all containing additional material and essays on the works. The complete Kerouac/Burroughs manuscript And the Hippos Were Boiled in Their Tanks was published for the first time in November 2008. Several of Burroughs early novels, including Junky and Naked Lunch, have been republished in posthumous “Restored Text” editions, incorporating material edited out of previous versions.

Bill Laswell’s Material collaborated with Burroughs to produce the 1989 album Seven Souls, wherein Burroughs recites passages from his book The Western Lands to musical accompaniment. The album was reissued in 1997 with 3 bonus remixes. In 1998, an additional unreleased six remixes (plus one previously released) were introduced on the album The Road To The Western Lands. Spring Heel Jack’s remix of the track ‘”The Road to the Western Lands” from this album was also included on their Oddities album from 2000.

Burroughs is featured on the 2000 compilation tribute album, Stoned Immaculate, on a track that pairs Jim Morrison yelping and groaning with Burroughs reading Morrison’s poetry. The music was recorded by the surviving Doors members in 2000 specifically for this album.

Burroughs was portrayed by Kiefer Sutherland in the 2000 film Beat, written and directed by Gary Walkow. Loosely biographical, the plot involves a car trip to Mexico City with Vollmer, Kerouac, Ginsberg, and Lucien Carr, and includes a scene of Vollmer’s shooting.

Burroughs was fictionalized in Jack Kerouac’s autobiographical novel On the Road as “Old Bull Lee”. He also makes an appearance in J. G. Ballard’s semi-autobiographical 1991 novel The Kindness of Women. In the 2004 novel Move Under Ground, Burroughs, Kerouac, and Neal Cassady team up to defeat Cthulhu.

Some research suggests that Burroughs is arguably the progenitor of the 2012 phenomenon, a belief of New Age Mayanism that an apocalyptic shift in human consciousness would occur at the end of the Mayan Long Count calendar in 2012. Although never directly focusing on the year 2012 himself, Burroughs had an influence on early 2012 proponents such as Terence McKenna and Jose Argüelles, and as well had written about an apocalyptic shift of human consciousness at the end of the Long Count as early as 1960’s The Exterminator.

Burroughs is portrayed by Ben Foster in the 2013 film Kill Your Darlings, directed by John Krokidas and written by Krokidas and Austin Bunn. The film tells the story of Lucien Carr (Dane DeHaan) and David Kammerer (Michael C. Hall), with appearances by actors playing Ginsberg (Daniel Radcliffe) and Kerouac (Jack Huston).

The Word Hoard, the collection of manuscripts that produced Naked Lunch, also produced parts of the later works The Soft Machine (1961), The Ticket That Exploded (1962), and Nova Express (1964). These novels feature extensive use of the cut-up technique that influenced all of Burroughs’ subsequent fiction to a degree. During Burroughs’ friendship and artistic collaborations with Brion Gysin and Ian Sommerville, the technique was combined with images, Gysin’s paintings, and sound, via Somerville’s tape recorders. Burroughs was so dedicated to the cut-up method that he often defended his use of the technique before editors and publishers, most notably Dick Seaver at Grove Press in the 1960s and Holt, Rinehart & Winston in the 1980s. The cut-up method, because of its random or mechanical basis for text generation, combined with the possibilities of mixing in text written by other writers, deemphasizes the traditional role of the writer as creator or originator of a string of words, while simultaneously exalting the importance of the writer’s sensibility as an editor. In this sense, the cut-up method may be considered as analogous to the collage method in the visual arts. New restored editions of The Nova Trilogy (or Cut-Up Trilogy), edited by Oliver Harris (President of the European Beat Studies Network) and published in 2014, included notes and materials to reveal the care with which Burroughs used his methods and the complex histories of his manuscripts.