In January 2018, ANC MP Mandla Mandela, Nelson Mandela's grandson by his first wife, Evelyn Mase, called for Winnie Mandela's role in the Asvat and Sepei murders to be probed. In October 2018 a new biography of Madikizela-Mandela concluded that she had been responsible for the murder of Asvat.
In April 2018, Joyce Seipei, the mother of Stompie Seipei, told media that she did not believe that Winnie Madikizela-Mandela was involved in her son’s murder. In a subsequent interview with the UK Independent, Joyce Seipei said that she had forgiven Madikizela-Mandela, and that during the TRC hearings, Madikizela-Mandela had told her, in the context of her son Stompie's murder: "...may God forgive me". After the TRC hearings, Madikizela-Mandela had provided financial support to Joyce Sepei's family, and Seipei's home was furnished by the ANC.
Winnie Madikizela-Mandela died at the Netcare Milpark Hospital in Johannesburg on 2 April 2018 at the age of 81. She suffered from diabetes and had recently undergone several major surgeries. She "had been in and out of hospital since the start of the year".
Madikizela-Mandela was granted a "Special Official Funeral" by the South African government. Her public funeral service was held at Orlando Stadium on 14 April 2018. Planning for Madikizela Mandela's funeral was largely handled by her daughters and Julius Malema, and the ANC reportedly had to "fight for space" on the programme. At the public service, ANC and South African President Cyril Ramaphosa "acknowledged" that the ANC failed to stand by Madikizela-Mandela's side during her legal troubles. Julius Malema, delivered an impassioned speech in which he criticised the United Democratic Front for distancing themselves from Madikizela-Mandela in the 1980s. Malema also criticised members of the National Executive Committee of the ANC Women's League for resigning in 1995, because they regarded Madikizela-Mandela as a "criminal". Madikizela-Mandela's daughter Zenani attacked those who "vilified" her mother, calling them hypocrites. After the public service, her body was interred at a cemetery in Fourways in the north of Johannesburg during a private memorial service.
In January 2018, the University Council and University Senate of Makerere University, Kampala, Uganda, approved the award of an honorary Doctor of Laws (LLD) degree to Winnie Nomzamo Madikizela-Mandela, in recognition of her fight against apartheid in South Africa.