The popular MTV show Pimp My Ride boosted his popularity even further, as it introduced him to a major audience in 2004. The show starred him as the host, who brings an individual's wrecked car to West Coast Customs, where it undergoes a rejuvenation. He continued hosting the show until its cancellation in 2007, those years can easily be seen as the most successful in his career.
Musically, he started the year off with the release of his second compilation album Appetite for Destruction featuring 50 Cent on one track, consisting mostly of tracks from his Dre period and songs that didn't make the cut for his fifth studio album Weapons of Mass Destruction, which was released in December 2004, entering the charts at 43 in the U.S. For this album, he reunited with Columbia Records, after having parted ways with producer and mentor Dr. Dre. The album managed to go gold, but yet again Xzibit was unhappy with the promotion and backing of his label, claiming that they were trying to promote him like Jessica Simpson, leaving the label in anger and going independent. His single "Hey Now (Mean Muggin)" featuring Keri Hilson marked his last chart success on the Billboard Hot 100, peaking at number 93, while the second single "Muthafucka" failed to chart. Aside from his music and Pimp My Ride, he starred in the movie Full Clip, alongside Busta Rhymes, guest-starred in CSI: Miami in the episode The Rap Sheet, released a concert documentary with his new group, eponymously titled Strong Arm Steady and hosted the 2004 MTV Europe Music Awards in Rome. In 2005, he collaborated with shock rock legend Alice Cooper on a track entitled "Stand" from the album Dirty Diamonds. This represented Cooper's first-ever foray into rap music. This year marks his most busy one, also being featured in three video games, The Chronicles of Riddick: Escape from Butcher Bay, where he lent his voice and likeness to the warden Abbott and Def Jam: Fight for NY and NFL Street 2, where he was a playable character.