In addition to the numerous mentions of Zen and nature, one topic that was briefly mentioned in Kawabata's lecture was that of suicide. Kawabata reminisced of other famous Japanese authors who committed suicide, in particular Ryūnosuke Akutagawa. He contradicted the custom of suicide as being a form of enlightenment, mentioning the priest Ikkyū, who also thought of suicide twice. He quoted Ikkyū, "Among those who give thoughts to things, is there one who does not think of suicide?" There was much speculation about this quote being a clue to Kawabata's suicide in 1972, two years after Mishima had committed suicide.
Kawabata apparently committed suicide in 1972 by gassing himself, but a number of close associates and friends, including his widow, consider his death to have been accidental. One thesis, as advanced by Donald Richie, was that he mistakenly unplugged the gas tap while preparing a bath. Many theories have been advanced as to his potential reasons for killing himself, among them poor health (the discovery that he had Parkinson's disease), a possible illicit love affair, or the shock caused by the suicide of his friend Yukio Mishima in 1970. Unlike Mishima, Kawabata left no note, and since (again unlike Mishima) he had not discussed significantly in his writings the topic of taking his own life, his motives remain unclear. However, his Japanese biographer, Takeo Okuno, has related how he had nightmares about Mishima for two or three hundred nights in a row, and was incessantly haunted by the specter of Mishima. In a persistently depressed state of mind, he would tell friends during his last years that sometimes, when on a journey, he hoped his plane would crash.