On 11 January 2018, FC Barcelona and Palmeiras reached an agreement regarding the transfer of Yerry Mina for the remainder of the current season and five more seasons, until 30 June 2023. This made him the first-ever Colombian to play for the club. The cost of the transfer was €11.8 million, and his release clause was set at €100 million.
On 8 August 2018, Mina signed with Premier League team Everton in a deal worth €30 million.
At the 2018 World Cup, Mina scored three goals for Colombia, all headers. Mina did not play in Colombia's opening 2–1 loss with Japan, but started at centre back in each of Colombia's remaining matches. In the group stage, he scored the opening goal in a 3–0 win over Poland, then scored the lone goal in a 1–0 win over Senegal which propelled Colombia to the top of their group and into the knockout stage. Against England in the round of sixteen, Mina tied the scoring 1–1 in the 93rd minute to send the game into extra time. Colombia went on to lose the game on penalty kicks, ending their tournament. With his three goals, he tied the record number of goals scored by a defender in a single World Cup tournament, sharing the record with Germans Paul Breitner in 1974 and Andreas Brehme in 1990.