Young Thug began his musical career in 2010, debuting as a guest appearance on rapper TruRoyal’s song “She Can Go”. After releasing the first three installments of his mixtape series I Came from Nothing throughout 2011 and 2012, Young Thug caught the attention of fellow Atlanta-based rapper Gucci Mane, who went on to sign Young Thug to his label 1017 Brick Squad Records, an Asylum/Atlantic imprint, in 2013. Thug subsequently released his first project on the label, his fourth mixtape, 1017 Thug. The mixtape was met with positive reviews from music critics, which noted it for its original style. 1017 Thug was included in a number of year-end lists for 2013, such as the Pitchfork Albums of the Year: Honorable Mention and Complex’s The 50 Best Albums of 2013. FACT called it the best mixtape of 2013, Rolling Stone placed it at number five on their 10 Best Mixtapes of 2013 and The Guardian placed it among The Five Best Mixtapes of 2013. Young Thug’s song “Picacho” was noted as one of the standout tracks from the mixtape; although it was not released as a single, the song was included on a number of 2013 year-end lists, such as Rolling Stone’s 100 Best Songs of 2013, Pitchfork’s The Top 100 Tracks of 2013, and Spin’s 50 Best Songs of 2013.

In July 2013, Complex included him in their list of 25 New Rappers to Watch Out For. In October 2013, Young Thug released his commercial debut single “Stoner”. The song spawned a number of unofficial remixes by several rappers, including Wale, Jim Jones, Jadakiss, Iamsu! and Trick-Trick, among others. Thug expressed his disapproval for the remixes, commenting “If you feel like my song isn’t tough enough to the point where you have to freestyle… Don’t think I’m happy that you’re doing it because of who you are. I’m ready for war.” His song “Danny Glover” also received a number of remixes by Waka Flocka Flame and Nicki Minaj, among others. In October 2013, Young Thug also appeared on a few tracks on 19 & Boomin by Metro Boomin, including “Some More”, the first song he made with Alex Tumay, who became his go-to engineer for almost everything from then until “Slime Season 2”. In December 2013, Thug performed at Fool’s Gold Day Off show in Miami, among Danny Brown, Trick Daddy and Travis Scott.

On January 18, 2014, Young Thug revealed that he had been offered $8.5 million to sign to Future’s Freebandz record label. In March 2014, Young Thug’s affiliation with Cash Money Records and its chief executive officer (CEO) Birdman, resulted in much speculation in the media about him signing to the label. However, the label’s publicist later stated this was untrue. On March 28, 2014, Ronald “Caveman” Rosario, director of Urban Music at 1017 Distribution, cleared the situation, stating that Young Thug signed a management deal with Birdman’s Rich Gang, not a record deal, and is still signed to 1017 Brick Squad.

In 2014, Thug also recorded several songs with Kanye West, who praised him for his ability to make songs so fast. Thug announced that he had upcoming mixtapes with Rich Homie Quan, Chief Keef and Bloody Jay. Young Thug would go on to be featured on the March 2014 cover of The Fader. On March 11, 2014, his debut single “Stoner”, was serviced to rhythmic contemporary radio in the United States by Asylum and Atlantic Records. On March 24, 2014, Thug stated his debut album would be titled Carter 6, referencing the highly acclaimed Tha Carter album series by American hip hop superstar Lil Wayne, who has been the biggest influence in Young Thug’s music career. Two days later, it was revealed that Young Thug was working on a collaborative album with American record producer Metro Boomin, which is titled Metro Thuggin and set for release in spring 2014. The first song from the project, titled “The BLanguage”, uses elements from Canadian rapper Drake’s “The Language”, was released the same day. In April 2014, Young Thug released a new 808 Mafia-produced song titled “Eww”, which was named one of the five best songs of the week by XXL. A remix of the song was supposed to be on Thug’s debut album with verses from Lil Wayne and Drake, but that never happened.

On June 17, 2014, Kevin Liles confirmed that Young Thug had been officially signed to his and Lyor Cohen’s label 300 Entertainment. On July 1, 2014, Asylum Records and Atlantic Records officially released Young Thug’s 2013 fan-favorite song “Danny Glover”, re-titling it “2 Bitches”. Also on July 1, Mass Appeal Records released “Old English”, the first single from their compilation album Mass Appeal Vol. 1, which features Young Thug alongside fellow American rappers ASAP Ferg and Freddie Gibbs. On October 16, 2014, the first single from Cash Money Records Rich Gang 2 compilation, was released titled “Take Kare”, featuring Young Thug and Lil Wayne. The December 4, 2014 issue of Rolling Stone called Young Thug the “most exciting new voice of hip-hop” and “hip-hop’s new crown prince.” At the end of the year, music critic Robert Christgau named Black Portland—Young Thug’s collaborative mixtape with Bloody Jay—the fourth best album of 2014.

In 2015, a series of data breaches leaked hundreds of unreleased tracks from Young Thug’s archives to the Internet. Young Thug’s planned debut album was set for release in 2015, and was said to be named Carter 6, in homage to Lil Wayne’s upcoming album, Tha Carter V. Lil Wayne, however, wasn’t happy about the tribute, telling the audience of a show in April 2015 to “stop listening” to Young Thug. After claiming he’s been threatened with lawsuits, Young Thug announced that he was changing the title to Barter 6 and clarified that it would be a mixtape rather than his debut album. Young Thug announced April 18, 2015, that his official debut album will be titled Hy!£UN35, which translates to “HiTunes”. In May 2015, after much confusion as to who he was signed to and managed by, having been aligned with Gucci Mane’s 1017 Records, Future’s Freebandz, Lyor Cohen’s 300 Entertainment and Birdman’s Rich Gang, Young Thug revealed “I manage myself. I’m signed with Atlantic. I have a big, special deal with Atlantic, and it’s only Atlantic. Birdman is my homie.” He also revealed he would be releasing another mixtape prior to the album, titled Tha Carter V.

Young Thug has six children by four women (three sons and three daughters). He became a father at the age of 17. In April 2015, he became engaged to Jerrika Karlae, who runs a swimsuit line and whose mother manages Young Dolph. Thug bought his first home in September 2016 after the release of his mixtape Jeffery. The home, based in Buckhead, Atlanta, is more than 11,000 square-feet, has six bedrooms, 11 bathrooms, a full bar, a theater room and a four-car garage.

Since his career began, Young Thug has had many run-ins with the law. In April 2015 after a Lil Wayne tour bus was fired at by members of the Bloods street-gang, Thug was one of the individuals involved in a lawsuit after the bus driver of the tour bus decided to sue Cash Money Records, Young Money Records, Birdman and Young Thug. A lawsuit was filed against Thug in January 2017 after Thug didn’t show up at a concert in Sahlen’s Stadium after a $55,000 contract was signed. This wasn’t the first time a lawsuit has been filed against Thug for not appearing at a concert, as a Texas production company filed a lawsuit against Thug in April 2016 after he failed to perform at a concert. Thug was cleared of battery in April 2017 after reportedly slapping a woman outside a nightclub in the previous month. The woman was arguing with Thug’s fiancée, Jerrika Karlae, when Thug supposedly stepped in and attacked the woman. The charges were dropped due to a lack of evidence. Young Thug’s gun and drug charges were dropped in April 2017 following a raid of his then-home in Sandy Springs, Georgia which resulted in Thug being charged with felony cocaine possession, felony marijuana possession and 3 counts of felony gun possession. Thug’s lawyers argued that police conducted the search without a warrant which led to the D.A dropping all charges except felony marijuana possession. It was reported in April 2017 that Thug was being sued by Heritage Select Homes for owing almost $2.2 million in house payments.

To circumvent their further spread of leaked tracks, Thug released the well-received compilation mixtapes Slime Season and Slime Season 2. Young Thug revealed in late June 2015 that he and Kanye West have discussed the prospect of a joint album together, both agreeing after a meeting in the spring. Details are still scarce, but Thug said Kanye was impressed after previewing his unreleased music. “I was letting him hear all the music. Then he said I was like Bob Marley and he wanted to do an album with me. I was like, ‘Let’s roll!'” the rapper said. Young Thug appeared on West’s 2016 album The Life of Pablo, and West tweeted that he would release further collaborations with Young Thug on Tidal. In July 2015, 300 Entertainment released a promotional single, “Pacifier”, in support of Young Thug’s debut album HiTunes (stylized as Hy!£UN35). The song features production from Mike Will Made-It, and was noted by critics for its experimentation with more extreme vocal scatting. On February 4, 2016, Young Thug released a mixtape titled I’m Up. On March 26, 2016, he released the final installment of the Slime Season series in Slime Season 3, declaring the mixtape the end of a phase marked by leaked material. Young Thug toured the United States on his May 2016 Hi-Tunes tour, which featured artists Dae Dae, TM88, and Rich The Kid.

Young Thug was featured in Calvin Klein’s Fall 2016 fashion campaign, along with Frank Ocean among others. On July 9, 2016, he announced his self-titled mixtape Jeffery was coming out soon. On August 16, 2016, Thug announced he would change his name to Jeffery for one week, the week during the release of the Jeffery mixtape. The album artwork features Young Thug dressed in an androgynous dress designed by Italian designer Alessandro Trincone, and was photographed by Garfield Lamond. The artwork went viral and prompted a wide range of responses on social media. In November 2016, he announced he was starting his own record label imprint called YSL records.

In December 2016, Thug joined the #fightpovertyagain campaign. On June 29, 2017, Thug donated all proceeds of a sold-out concert to Planned Parenthood, stating on Twitter that “I was a teenage parent. Planned+unplanned parenthood is beautiful.”

In March 2017, Thug was featured on Drake’s songs “Sacrifices” and “Ice Melts” on the former’s commercial mixtape, More Life, the former song being alongside 2 Chainz. He was featured on Calvin Harris’ song “Heatstroke” along with Ariana Grande and Pharrell Williams, released in March 2017. In April 2017, Young Thug announced the commercial mixtape Beautiful Thugger Girls, originally titled E.B.B.T.G. The project was executively-produced by Drake and was released on June 16, 2017. In August, he featured on Camila Cabello’s single “Havana”, which peaked at number one on the Billboard Hot 100, becoming his first number one hit. In September 2017, he released a joint EP with DJ Carnage titled Young Martha. In October 2017, Thug released a collaborative mixtape with Future titled Super Slimey. It includes tracks recorded by each of the artists individually as well as both together, and features guest vocals from rapper Offset.

On September 24, 2017, Thug was arrested in Brookhaven, Georgia on multiple drug possession charges and possession of a firearm. Thug was released on bond on September 27, 2017. On September 7, 2018, Thug was charged with possession and intent to distribute meth, hydrocodone and marijuana. He’s also charged with possession of amphetamine, Alprazolam, codeine (2 counts) and a firearm.

In 2018, Young Thug released the single “Ride for Me”, a collaboration by A-Trak, Falcons, and 24hrs via A-Trak’s record label Fool’s Gold. He released the EP Hear No Evil in April 2018. Young Thug co-wrote and provided background vocals on Childish Gambino’s “This Is America”, which debuted at number one on the Billboard Hot 100 chart for May 19, 2018. In August 2018, he released another compilation album, Slime Language.

In February 2018, Young Thug rebranded himself “SEX”.

On May 23, 2019, Young Thug released the single “The London”, featuring American rappers J. Cole and Travis Scott. On the same day, also announced his forthcoming debut studio album, which was originally called Gold Mouf Dog. On July 19, 2019, Young Thug announced that the album had been renamed to So Much Fun. On August 10, 2019, Young Thug announced the album’s release date and cover art. The track listing was revealed on August 15. The album was released on August 16, 2019, the rapper’s 28th birthday. It features guest appearances from Future, Machine Gun Kelly, Gunna, Lil Baby, Lil Uzi Vert, Lil Duke, 21 Savage, Doe Boy, Lil Keed, Quavo, Juice Wrld, Nav, J. Cole, and Travis Scott. The album debuted at number one on the US Billboard 200. On October 31, 2019, a song from the album called “Hot”, featuring American rapper and fellow labelmate Gunna, became the album’s second single due to a remix with an additional feature from Travis Scott. “The London”, which peaked at number 12 and 11, respectively, on the Billboard Hot 100. The deluxe edition of the album was released on December 20, 2019, with extra guest appearances from Gunna and Travis Scott, separately and including the remix of “Hot”.

On October 20, 2019, Young Thug appeared on The Tonight Show Starring Jimmy Fallon alongside Gunna.

On April 29, 2020, Young Thug and American singer Chris Brown announced their collaborative mixtape, Slime & B. It was released on May 5, 2020, which was the latter’s 31st birthday. It features guest appearances from Major Nine, Gunna, Lil Duke, Too Short, E-40, HoodyBaby, and Future. The mixtape’s lead single, “Go Crazy”, peaked at number 9 on the Billboard Hot 100, becoming Thug’s highest-charting single as a lead artist.

On September 25, 2020, Thug was featured alongside British rapper M.I.A. on American rapper and singer Travis Scott’s single “Franchise”, which debuted at number one on the Billboard Hot 100, making Thug’s second number one single. Throughout the year, he had fourteen chart entries on the Hot 100, due to a lot of collaborations with other artists.