Kishii's first lead film role came in the 2017 Yukihiro Morigaki film Goodbye, Grandpa! (おじいちゃん、死んじゃったって, Ojiichan, shinjyattatte) as Yoshiko Haruno, the granddaughter of a recently deceased family patriarch. Sarah Ward of Screen Daily described her performance as "especially impressive, her wise-beyond-her-years demeanour helping to flesh out a protagonist largely tasked with observing everyone around her". Kishii's performance in Goodbye, Grandpa! won her a Best Newcomer Award at the 39th Yokohama Film Festival. That same year she played Sumire Michibata in the TBS television series Rental Lovers (レンタルの恋, Rentaru no koi) and Miyuki Asakawa in the Kiyoshi Kurosawa science fiction drama Foreboding on Wowow. In 2018 Kishii took on roles in two NHK dramas: the drama School Lawyer (やけに弁の立つ弁護士が学校でほえる, Yakeni ben no tatsu bengoshi ga gakkō de hoeru), as middle school teacher Shiori Mochozuki; and Manpuku, the 99th NHK asadora, as Taka Kōda. She also appeared in the Fuji TV adaptation of The Count of Monte Cristo.
