Gurriel became the first Astro with a run and RBI in seven consecutive games, and the fifth to homer in five consecutive games, on July 7, 2019, including a game-tying grand slam in doing so in an 11–10 win versus the Los Angeles Angels. He won the AL Player of the Week Award for the week ending July 8, his second weekly honor, after homering in all five of the Astros games for a total of six, among nine hits and an OPS of 1.812. He went on to win the AL Player of the Month Award for July, his first time, after batting .398, .427 OBP, .837 SLG, 18 runs scored, seven doubles, 12 home runs, 31 RBIs over 24 games. In a 14–3 romp over the Colorado Rockies on August 7, Gurriel homered and tied J. R. Towles with eight RBIs for the club record in one game.
In 2019, Gurriel batted .298/.343/.541 with 31 home runs and 104 RBIs (9th in the AL) in 564 at bats..